Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization
Advanced Science, EarlyView.Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay +3 more
wiley +1 more source
Association of GCH1 polymorphism with Parkinson disease susceptibility: A meta-analysis. [PDF]
Medicine (Baltimore)Wang J, Shao F, Lin H, Zhan S, Wang J.
europepmc +1 more source
Advanced Science, EarlyView.This schematic representation illustrates the interaction mechanisms between polyphenolic compounds and various materials (metals, proteins, polysaccharides, alkaloids, etc.). And explains the potential clinical application value of these materials (nanoparticles, coatings, films, capsules, and hydrogels constructed using polyphenols) in the fields of ...
Songwen Xue +6 more
wiley +1 more source
Interrelationship between PQ exposure and Parkinson disease: A systematic review and meta-analysis. [PDF]
Medicine (Baltimore)Ba RQ +6 more
europepmc +1 more source
Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities
Advanced Science, EarlyView.The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley +1 more source
The Gut-Brain Axis in Parkinson disease: Emerging Concepts and Therapeutic Implications. [PDF]
Mov Disord Clin PractMenozzi E, Schapira AHV, Borghammer P.
europepmc +1 more source
Expression Patterns of Retinoblastoma Protein in Parkinson Disease
, 2003 Kelly L. Jordan‐Sciutto +4 more
openalex +1 more source
Dual Hydrophilic‐Hydrophobic Core Architecture in Soy Glycinin Amyloid Fibrils Revealed by Cryo‐EM
Advanced Science, EarlyView.While high‐resolution structures of animal and microbial amyloids are extensively characterized, the structural principles underlying plant‐derived amyloids remain largely unexplored. The study addresses this fundamental gap in knowledge by determining the first near‐atomic‐resolution cryo‐EM structures of amyloid fibrils derived from soy glycinin ...
Saiya Li +5 more
wiley +1 more source
Stability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years. [PDF]
NeurologyRäty V +8 more
europepmc +1 more source
Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review
Advanced Science, EarlyView.This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu +7 more
wiley +1 more source