Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background
BiomedicinesBackground/Objectives: Cognitive impairment often occurs in various parkinsonian syndromes. The course of deficits in cognitive functions ranges from mild cognitive decline to severe deterioration. Affected cognitive domains are also variable.
Christos Koros +4 more
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Apraxia in progressive nonfluent aphasia [PDF]
, 2010 The clinical and neuroanatomical correlates of specific apraxias in neurodegenerative disease are not well understood. Here we addressed this issue in progressive nonfluent aphasia (PNFA), a canonical subtype of frontotemporal lobar degeneration that has
Rohrer, J.D., Rossor, M.N., Warren, J.D.
core
Pedunculopontine Nucleus Deep Brain Stimulation for Parkinsonian Disorders: A Case Series [PDF]
, 2020 Viswas Dayal +12 more
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Movement Disorders Clinical Practice, EarlyView.Background The determinants of the severity of idiopathic normal pressure hydrocephalus (iNPH) have not been examined previously. Objective To reveal the clinical determinants of the clinical severity of iNPH in detail. To provide some clinical remarks and contributions to the understanding of the pathophysiology.
Halil Onder +3 more
wiley +1 more source
Clinical features and outcomes of hospitalised patients with COVID-19 and Parkinsonian disorders: A multicentre UK-based study. [PDF]
PLoS One, 2023 Sorrell L +14 more
europepmc +2 more sources
Freezing of Gait in Parkinson’s Disease: A Perceptual Cuase for a Motor Impairment? [PDF]
, 2009 While freezing of gait (FOG) is typically considered a motor impairment, the fact that it occurs more frequently in confined spaces suggests that perception of space might contribute to FOG.
Almeida, Quincy J., Lebold, Chad A.
core +1 more source
The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders [PDF]
, 2013 Timothy Rittman +7 more
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Movement Disorders Clinical Practice, EarlyView.Abstract Background Mild behavioral impairment (MBI) is a syndrome characterized by the later‐life onset of neuropsychiatric symptoms (NPS) and serves as a potential marker for dementia. In Parkinson's disease (PD), MBI has been associated with worse cognition, cortical atrophy, and altered connectivity.
Gabriel D. Pinilla‐Monsalve +4 more
wiley +1 more source
PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism. [PDF]
, 2006 We analyzed the PINK1 gene in 58 patients with early-onset Parkinsonism and detected the homozygous mutation W437X in 1 patient. The clinical phenotype was characterized by early onset (22 years of age), good re- sponse to levodopa, early fluctuations ...
CRISCUOLO C +10 more
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Gait Disorders in Parkinsonian Monkeys with Pedunculopontine Nucleus Lesions: A Tale of Two Systems [PDF]
, 2013 David Grabli +8 more
openalex +1 more source