Results 111 to 120 of about 1,313,066 (193)
Parkinson's Disease and Retinal Age Gap: A Cross‐Sectional Analysis
Movement Disorders, EarlyView.Abstract Background
Deep‐learning models are capable of predicting age from retinal scans and the difference between this and chronological age, retinal age gap, has been shown to be significantly associated with risk of mortality, cardiovascular diseases, and kidney failure.Akshay Narayan, Oscar Earle, Yukun Zhou, Axel Petzold, Rimona S. Weil, Alastair K. Denniston, Anthony P. Khawaja, Pearse A. Keane, Zhuoting Zhu, Siegfried K. Wagner +9 morewiley +1 more sourceParkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations
, 2013 Atypical Parkinsonism associated with white matter pathology has been described in cerebrovascular diseases, mitochondrial cytopathies, osmotic demyelinating disorders, leukoencephalopathies leukodystrophies, and others.Rademakers, Rosa, Dickson, Dennis W., Miller, B. B., Ghetti, Bernardino, Miller, Bradley B., Van Gerpen, Jay A., Shuster, E. A., Swerdlow, R. H., Börjesson-Hanson, Anne,, Sundal, Christina,, Roeber, Sigrun, Aasly, Jan, Borjesson-Hanson, Anne, Tselis, A., Wszolek, Zbigniew K., Stoessl, John A., Josephs, Keith A., Wider, C., Shuster, Elizabeth A., Josephs, K. A., Van Gerpen, J. A., Swerdlow, Russell H., Garbern, J., Spina, Salvatore, Broderick, Daniel, Broderick, D., Fujioka, S., Ghetti, B., Ross, Owen, Ross, O. A., Wszolek, Z. K., Rademakers, R., Dickson, D. W., Baker, M., Uitti, R. J., Garbern, James, Uitti, Ryan J., Spina, S., Fujioka, Shinsuke, Sundal, Christina, Roeber, S., Stoessl, A. J., Nicholson, A. M., Wider, Christian, Nicholson, Alexandra M., Tselis, Alex, Aasly, J., Baker, Matt +47 morecore +1 more sourceFifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism
Movement Disorders, EarlyView.Abstract Background
Bilateral pallidal deep brain stimulation (GPi‐DBS) is effective for dystonia. Long‐term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives
To assess 15‐year dystonia outcomes and characterize parkinsonism after bilateral GPi‐DBS.Clément Desjardins, Cécilia Bonnet, Elena Moro, David Grabli, Valérie Fraix, Marie‐Laure Welter, Laurent Vercueil, Soledad Navarro, Carine Karachi, Thibaud Charrier, Sylvie Raoul, Mathilde Guibourd de Luzinais, Emmanuel Cuny, Stéphan Chabardes, Pierre Burbaud, Dominique Guehl, Pascal Derkinderen, Marie Vidailhet, on behalf of the French SPIDY Study Group, Olivier Detante, Valérie Fraix, Pierre Pollak, Laurent Vercueil, Yves Agid, David Grabli, Jean‐Luc Houeto, Valérie Mesnage, Marie Vidailhet, Marie‐Laure Welter, Pierre Césaro, Luc Defebvre, Alain Destée, Pierre Krystkowiak, Alim‐Louis Benabid, Stephan Chabardes, Adnan Koudsie, Philippe Cornu, Soledad Navarro, Serge Blond, Gustavo Touzet, Abdelhamid Benazzouz, Bernard Pidoux, François Cassim, Sylvie Grand, Jean‐François Le Bas, Didier Dormont, Jean‐Pierre Pruvo, Christine Delmaire, Claire Ardouin, Bernard Pillon, Valérie Hahn‐Barma, Kathy Dujardin. +51 morewiley +1 more sourceFeasibility and Immediate Effects of Dynamic Exercise Using Mixed Reality for Balance Improvement in Older Adults and Individuals With Neurologic Disorders
Archives of Rehabilitation Research and Clinical TranslationObjective: To investigate the feasibility and immediate effects of dynamic exercise using mixed reality (MR), a technology that allows real-time interaction between physical surroundings and computer-generated virtual objects, in older adults and ...Kazuki Ushizawa, OTR, MS, Shintaro Uehara, PT, PhD, Akiko Yuasa, PT, PhD, Daisuke Matsuura, MD, PhD, Yoshitaka Wada, MD, PhD, Hirohisa Watanabe, MD, PhD, Yohei Otaka, MD, PhD +6 moredoaj +1 more sourceIntegrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective
To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...Mirco Macchi, Aurélien Ginolhac, Tony Heurtaux, Borja Gomez‐Ramos, Lasse Sinkkonen, Enrico Glaab, on behalf of the NCER‐PD Consortium, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlaan, Anne Grünewald, Armin Rauschenberger, Clarissa P.C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby +127 morewiley +1 more sourceAdult‐Onset Dystonia Related to PRKRA (DYT16): A Predictor of Favorable Deep Brain Stimulation Outcome
Movement Disorders Clinical Practice, EarlyView.Ingrid Lorena da Silva Gomes, Eduardo Drews Amorim, Juan Sebastián Sánchez León, Thomas Hugentobler Schlickmann, Yuri Ferreira Felloni Borges, Artur Francisco Schumacher Schuh, Daniel Teixeira‐dos‐Santos, Sheila Trentin, Thais Lampert Monte, Bruno Samuel Fraiman de Oliveira +9 morewiley +1 more sourceLewy Body Disease Across Aging: Clinical and Neuropathological Correlates in a Population Brain Bank
Movement Disorders, EarlyView.Abstract Background
Lewy body disease (LBD) is defined by neuronal α‐synuclein pathology, but how Braak‐staged LBD relates to mixed neuropathology and clinical manifestations within a single population‐based cohort remains incompletely characterized. This is especially relevant in cohorts enriched for younger individuals, which may better inform real ...Vitor Ribeiro Paes, Felipe Luiz Pereira, Caroline Matos Silva, Filipe Oto Cunha de Moraes, Inês Liguori Padrão, Alberto Fernando Oliveira Justo, Roberta Diehl Rodriguez, Michel Satya Naslavsky, Renata Elaine Paraizo Leite, Carlos Augusto Gonçalves Pasqualucci, Mayana Zatz, Eduardo Ferriolli, Claudia Kimie Suemoto, Lea Tenenholz Grinberg +13 morewiley +1 more source
