Results 101 to 110 of about 74,974 (313)

Parkinsonism and spastic paraplegia type 7: Expanding the spectrum of mitochondrial Parkinsonism

, 2019
Background Pathogenic variants in the spastic paraplegia type 7 gene cause a complicated hereditary spastic paraplegia phenotype associated with classical features of mitochondrial diseases, including ataxia, progressive external ophthalmoplegia, and ...
Jon Infante, Elena Martínez‐Sáez, Barahona-Hernando, Raúl, Beatriz De la Casa‐Fages, Adolfo López de Munaín, Raúl Barahona‐Hernando, Schlüter, Agatha, Jericó, Ivonne, Agatha Schlüter, Sola Vendrell, Emma, García-Barcina, María, Ian Holt, Saez-Villaverde, Raquel, Mikel Muñoz‐Oreja, Catalina, Irene, Germán Morís, Miguel Urtasun, Antonella Spinazzola, Olaskoaga, Ander, Martínez-Sáez, Elena, López de Munaín, Adolfo, Fernández-Pelayo, Uxoa, Raquel Saez‐Villaverde, Grandas Pérez, Francisco Javier, Gorka Fernández‐Eulate, Urtasun, Miguel, Victoria Zelaya, Francisco Grandas, Holt, Ian, Montserrat Ruiz, María García‐Barcina, Irene Catalina, Gamez, Josep, Fernández-Eulate, Gorka, Zelaya, Victoria, Josep Gamez, Ivonne Jericó, Jose Luis Muñoz‐Blanco, Morís, Germán, Muñoz-Blanco, Jose Luis, Álvarez, Victoria, Aurora Pujol, Pujol, Aurora, Spinazzola, Antonella, Zulaica, Miren, Miren Zulaica, Uxoa Fernández‐Pelayo, Victoria Álvarez, Infante, Jon, Ruiz, Montserrat, Ander Olaskoaga, Muñoz-Oreja, Mikel, Emma Sola, De la Casa-Fages, Beatriz   +53 more
core   +1 more source

Parkinsonism caused by adverse drug reactions: a case series

Journal of Medical Case Reports, 2011
Introduction Parkinsonism puts a high direct cost burden on both patient and caregiver. Several reports of drug-induced parkinsonism have been published, but to the best of our knowledge, there has not been any report of quinine or halothane inducing ...
Agaba Emmanuel I, Ugoya Solomon O, Daniyam Comfort A   +2 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

parkin mutation dosage and the phenomenon of anticipation: a molecular genetic study of familial parkinsonism

BMC Neurology, 2005
Background parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations leads to early-onset parkinsonism, while having one mutation may predispose to late-onset disease.
Schellenberg Gerard D, Nutt John G, Montimurro Jennifer S, Moses Lina, Poorkaj Parvoneh, Payami Haydeh   +5 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Demographic and Clinical Profile of Patients with Parkinsonism in Northwestern Nigeria

Nigerian Journal of Medicine
Introduction: Parkinsonism is a disorder characterised by bradykinesia, rigidity, tremors and postural or gait abnormality of many aetiologies with idiopathic Parkinson’s disease (PD) topping the list of causes.
Halimat Hassan Amin, Salisu Abdullahi Balarabe, Abdullahi Ibrahim Augie, Kenechukwu Celsus Eze, Ochiaga Olisa, Farouk Kabir Umar   +5 more
doaj   +1 more source

Vascular parkinsonism: A review on management updates

Annals of Indian Academy of Neurology, 2019
“Vascular parkinsonism (VP)” is a condition which presents with the clinical features of parkinsonism that are presumably caused by cerebrovascular disease.
Thilini B Udagedara, Alahakoon Mudiyanselage Buddhika Dhananjalee Alahakoon, Inuka Kishara Goonaratna   +2 more
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source