Results 121 to 130 of about 74,974 (313)

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

DIFFERENTIAL DIAGNOSIS OF PARKINSONISM

, 2015
Паркинсонизм характеризуется двигательными нарушениями – гипокинезией, ригидностью, тремором покоя, постуральной неустойчивостью. Нозологическая диагностика при выявлении синдрома паркинсонизма требует тщательного обследования.Проведен анализ диагностики
Ures’eva, Irina Vladimirovna, Shestakova, Marija Vladislavovna, Vasilenko, Andrej Fedorovich, Sadirin, Anton Vladimirovich, Artemova, Natal’ja Sergeevna, Istomina, Vera Vladimirovna   +5 more
core   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Mutation in theSYNJ1Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism

, 2013
Autosomal recessive, early-onset Parkinsonism is clinically and genetically heterogeneous. Here, we report the identification, by homozygosity mapping and exome sequencing, of a SYNJ1 homozygous mutation (p.Arg258Gln) segregating with disease in an ...
Fang, Mingyan, Barbosa, Egberto R., TASSORELLI, CRISTINA, Oostra, Ben A., Oostra, B.A., Fang, M., Wang, J., Sabina Pappatà, QUARANTELLI, MARIO, Oostra, B. A., Fengping Xu, Breedveld, Guido J., Annesi, G, Xu, F., Pappata, S, Quattrone, A., Pappata, Sabina, Simone Olgiati, Barbosa, ER, Oostra, Ben, BARONE, Paolo, Marina Picillo, Quattrone, Aldo, Guido J. Breedveld, Bloem, B., Breedveld, G.J., Erro, R., Barone, P., Graafland, Josja, PICILLO, MARINA, Aldo Quattrone, Olgiati, Simone, Jun Wang, Marialuisa Quadri, Barbosa, E.R., Fang, MY, Hsin F. Chien, International Parkinsonism Genetics Network, Vincenzo Bonifati, Olgiati, S., Breedveld, Guido, Barbosa, Egberto R, Bonifati, V., Egberto R. Barbosa, Ben A. Oostra, Warrenburg, B.P.C. van de, Picillo, M., Breedveld, G. J., Erro, R, Marianna Amboni, Quadri, Marialuisa, Breedveld, Guido J, Quarantelli, M., Mario Quarantelli, Barone, P, Oostra, Ben A, BONO, GIORGIO GIOVANNI, Bin Wu, Erro, Roberto, Amboni, M, Wang, J, Chien, HF, Mingyan Fang, Sabina Pappat?, Wu, Bin, Chien, Hsin F, Quattrone, A, Xu, Fengping, Quarantelli, M, Wang, Johnny, Chien, H. F., Josja Graafland, Barbosa, E. R., Wu, B., Bonifati, Vincenzo, Graafland, J., Amboni, M., Annesi, G., Roberto Erro, Paolo Barone, Wang, Jun, AMBONI, Marianna, Grazia Annesi, Chien, H.F., Pappatà, S., Xu, FP, Annesi, Grazia, Quadri, M., Chien, Hsin F., Picillo, M   +89 more
core   +1 more source

Parkinsonism following ventriculoperitoneal shunt for treating hydrocephalus:clinical analysis on three cases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
Objective To explore the clinical presentations, imaging features, probable pathogenesis and therapy of parkinsonism following ventriculoperitoneal shunt (VPS) in hydrocephalus.
Sheng-de LI, Lin WANG, Hong-zhi GUAN, Jun-ji WEI, Bin PENG, Xin-hua WAN   +5 more
doaj  

Long‐Term Neurologic Exam Findings in People Diagnosed and Treated During Acute HIV Infection

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Evaluate clinical and laboratory correlates of abnormal neurologic exam findings after acute HIV infection (AHI). Methods Participants from the RV254/SEARCH 010 cohort in Bangkok underwent standardized neurologic examinations at Weeks 0 (AHI), 12, 96, and 288 following antiretroviral therapy (ART).
Kathryn B. Holroyd, Tyler Hamby, Carlo Sacdalan, Somchai Sriplienchan, Pathariya Promensa, Luxenaree Poonpitak, Netsiri Dumrongpisutikul, Eugène Kroon, Sandhya Vasan, Robert Paul, Ferron O'Campo, Lydie Trautmann, Phillip Chan, Serena Spudich, on behalf of the RV254/SEARCH 010 Study Team, Julie Ake, Sandhya Vasan, Lydie Trautmann, Merlin Robb, Trevor Crowell, Donn Colby, Diane Bolton, Shelly Krebs, Leigh Ann Eller, Morgane Rolland, Rasmi Thomas, Dominic Paquin Proulx, Suteeraporn Pinyakorn, Tyler Hamby, Mark de Souza, Ellen Turk, Amber Moodley, Gerald Quarles, Jintanat Ananworanich, Denise Hsu, Victoria Polonis, Nelson Michael, Sheila Peel, COL Eric Garges, Alexandra Schuetz, Siriwat Akapirat, Bessara Nantapinit, Pornsuk Visudhiphan, Saowanit Getchalarat, Nampueng Churikanont, Sangsulee Thamakaison, Somchai Sriplienchan, Carlo Sacdalan, Pathariya Promsena, Luxe‐naree Poonpitak, Eugene Kroon, Nitiya Chomchey, Jintana Intasan, Varaporn Pothipala, Ferron Ocampo, Nittaya Phanuphak, Nipat Teeratakulpisan, Yuwaree Pichitchok, Anchalee Avihingsanon, Opass Putcharoen, Kiat Ruxrungtham, Thanyawee Puthanakit, Sopark Manasnayakorn, Phandee Watanaboonyongcharoen, Rungsun Rerknimitr, Irini Sereti, Daniel Douek, Eli Bortiz, Frank Maldarelli, Mary Kearney, Serena Spudich, Phillip Chan, Lishomwa Ndhlovu, Guinevere Li, Michael Corley, Victor Valcour, Peter Hunt, Jacob Estes, Afam Okoye, Jeff Lifson, Claire Deleage, Nicolas Chomont, Andres Finzi, Lyle McKinnon, Henrik Zetterberg, Robert Siliciano, Robert Paul, Julie Mannarino, Jonathan Li, John Mellors, Josh Cytkor, Dan Barouch, Michael Seaman, Boris Juelg, Alex Shalek, Timothy Schacker, Ashley Haase, Mario Stevenson, Wenjun Li, Arthur Kim, Sharon Lewin, Adam Carrico, Susana Valente, Fred Hutchinson, Josh Schiffer, Guido Ferrari, Beau Ances, Alberto Bosque, Katharine Bar, Killian Pohl, David Ho, Yaoxing Huang, Michael Busch, Mohamed Abdel‐Mohsen, Johanna Gostner, Brian Agan, Fatah Kashanchi, Greg Laird, Kathryn Holroyd   +118 more
wiley   +1 more source

Prevalence of Parkinson’s disease and other types of Parkinsonism in Al Kharga district, Egypt

, 2013
Hamdy N El-Tallawy,1 Wafaa M Farghaly,1 Ghaydaa A Shehata,1 Tarek A Rageh,1 Nabil M Abdel Hakeem,2 Mohamed Abd Al Hamed,1 Reda Badry1 1Department of Neurology, Assiut University, 2Al-Azhar University – Assiut branch, Assiut, Egypt Abstract ...
El-Tallawy HN, Shehata GA, Farghaly WM, Badry R, Abd Al Hamed M, Abdel Hakeem NM, Rageh TA   +6 more
core  

Parkinsonism induced by solvent abuse

, 1994
We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner.
Sanford P. Markey, Markey, S. P., Stanley Hashimoto, Ryan J. Uitti, Shinotoh, H., Hayward, M., Barry J. Snow, Vingerhoets, F. J., Hitoshi Shinotoh, Francois J. G. Vingerhoets, Richmond, J., Markey, C. J., Calne, D. B., Donald B. Calne, Hashimoto, S., Margo Hayward, Uitti, R. J., Carol J. Markey, Snow, B. J., John Richmond   +19 more
core   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source