Results 141 to 150 of about 74,974 (313)
Advanced Materials Interfaces, EarlyView.PEG‐guided mitochondrial surface engineering supports structural stabilization and controlled presentation of cell‐penetrating peptides. CPP–PEG‐modified mitochondria exhibit enhanced cellular uptake and uptake‐associated respiratory modulation, providing a proof‐of‐concept framework for modular organelle engineering and future bioenergetic modulation ...
Masahiro Shiraishi +9 more
wiley +1 more source
Von Economo’s disease and postencephalitic parkinsonism responsive to carbidopa and levodopa
, 2018 Daniel Y Bigman, Bradford D Bobrin Department of Psychiatry, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA Abstract: Postencephalitic parkinsonism (PEP) is currently perceived as having a very close etiologic ...
Bigman DY, Bobrin BD
core
Vascular Parkinsonism: A clinical review
, 2008 Over the last 75 years there has been continuous debate about the existence of vascular parkinsonism (VP). The condition has been named and renamed several times, with terms such as arteriosclerotic parkinsonism, arteriosclerotic pseudo-parkinsonism and ...
Grosset, D.G., Benamer, H.T.
core +1 more source
PCN ReportsBackground Valbenazine is used to treat dyskinesia and is generally associated with limited side effects; however, a few cases with the adverse effect of parkinsonism are reported in the literature.
Yasuhito Nagai +2 more
doaj +1 more source
Remote Control of Hand Actuators via Glove Sensors for Medical Care Applications
Advanced Robotics Research, EarlyView.This study presents a novel textile‐based sensory glove–actuator system for remote medical care, explored through finite element simulations. By integrating capacitive sensors, pneumatic actuators, and machine learning, the system models real‐time hand movement control.
Bahman Taherkhani, Mahdi Bodaghi
wiley +1 more source
Advanced Science, EarlyView.Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei +15 more
wiley +1 more source
Advanced Science, EarlyView.Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu +14 more
wiley +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Advanced Science, EarlyView.An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong +14 more
wiley +1 more source