Results 161 to 170 of about 61,853 (265)

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Magnetic resonance imaging volumetry in atypical parkinsonism: current evidence and neuroradiological perspectives. [PDF]

Front Aging Neurosci
Migda B, Madetko-Alster N, Migda A, Kutyłowski M, Alster P.   +4 more
europepmc   +1 more source

Ultrathin, Fully Solution‐Processed P(VDF‐TrFE) Piezoelectric Sensor Matrix for Electronic Skin

Advanced Electronic Materials, EarlyView.
An ultrathin, fully solution‐processed 4×$\times$4 piezoelectric sensor array is developed for skinconformal electronicskin applications. The device integrates inkjetprinted polymer electrodes with a 226 nm P(VDFTrFE) active layer on a 4.53 μm$\umu{\rm m}$ Parylene C substrate, enabling extreme flexibility and robust tactile sensing. The array exhibits
Ninja Kajas, Karem Lozano Montero, Leena Ukkonen, Veikko Surakka, Matti Mäntysalo   +4 more
wiley   +1 more source

Nrf2/NOX2 Pathway Dysregulation and Oxidative Stress Biomarkers in Gaucher Disease-Associated Parkinsonism: Insights Into a Potential Therapeutic Target. [PDF]

J Cell Mol Med
Ardizzone A, Lanza M, Capra AP, Casili G, Bulzomì M, Luca F, Paterniti I, Campolo M, Esposito E.   +8 more
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Shortening the SWAL-QOL: Is it possible to create a valid short form? [PDF]

Parkinsonism Relat Disord
Sevitz JS, Harel D, Troche MS.
europepmc   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Risk of Parkinsonism After Exposure to Different Types of Gadolinium-Based Contrast Agents: A Nationwide Population-Based Cohort Study of 222,977 Individuals. [PDF]

Korean J Radiol
Shin NY, Park SK, Kim B, Han K, Han K, Kim J, Lee SK, Ahn SV.   +7 more
europepmc   +1 more source

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu, Zhiwei Fang, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan   +7 more
wiley   +1 more source

A case report: Neuroimaging in an atypical presentation of Parkinson's disease. [PDF]

S Afr J Psychiatr
Sotobe Mose SNF, Lowton K.
europepmc   +1 more source