Advanced Science, EarlyView.This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim +19 more
wiley +1 more source
Glutathione Decreases Parkinsonism-Induced Ferroptosis and Oxidative Stress Through the Inhibition of the TRPM2 Channel in Neuronal Cells. [PDF]
Pharmacol Res PerspectGüzel E +2 more
europepmc +1 more source
The metabolism of orally administered
, 1969 Donald B. Calne +3 more
openalex +1 more source
Advanced Science, EarlyView.The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao +10 more
wiley +1 more source
Paradoxical Use of a Demand Pacemaker in Treatment of Supraventricular Tachycardia Due to the Wolff-Parkinson-White Syndrome [PDF]
, 1968 Gerald F. Ryan +3 more
openalex +1 more source
RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
Advanced Science, EarlyView.The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao +9 more
wiley +1 more source
Case Report: Lewy body dementia with unusual psychotic symptoms, atypically late parkinsonism, and patient sensitivity to first generation antipsychotics. [PDF]
Front PsychiatryErcika L, Taube M.
europepmc +1 more source
Ability to cycle despite severe freezing of gait in atypical parkinsonism in Fahr's syndrome. [PDF]
, 2011 Bhatia, KP +3 more
core +1 more source
Depressive symptoms in Parkinson patients referred for thalamotomy. [PDF]
, 1967 Jonathan Warburton
openalex +1 more source
Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species
Advanced Science, EarlyView.This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu +15 more
wiley +1 more source