Results 241 to 250 of about 74,974 (313)

Early diabetes‐like phenotypes in germ‐free mice induced by gut microbiota from patients with type 2 diabetes

Animal Models and Experimental Medicine, EarlyView.
Gut microbiota from patients with type 2 diabetes induced early diabetes‐like phenotypes in germ‐free mice, including progressive glucose intolerance and mild renal injury. Longitudinal profiling revealed persistent dysbiosis preceding stable metabolic dysfunction, with coordinated fecal and plasma metabolite alterations and a prominent L‐Dopa ...
Jianghao Feng, Xing Liu, Hua Zhu, Yun Yang, Wei Liu, Xiaoliang Jiang, Zhiwei Yang   +6 more
wiley   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism. [PDF]

Ann Neurol
Ono D, Sekiya H, Maier AR, Graff-Radford NR, Wszolek ZK, Dickson DW.   +5 more
europepmc   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Deep brain stimulation in <i>VPS13C</i>-associated Parkinson's disease: a longitudinal case study. [PDF]

Clin Park Relat Disord
Sumikura H, Tani N, Yoshino H, Hattori N, Sakaguchi M.   +4 more
europepmc   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Daily‐Life, Sensor‐Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Sensitive outcome measures are critical for evaluating the efficacy of novel treatments for Parkinson's disease (PD). In this study, we assess the sensitivity to change of sensor‐derived daily‐life tremor measures over 2 years in unmedicated and medicated persons with early PD.
Nienke A. Timmermans, Ioan Gabriel Bucur, Diogo C. Soriano, Erik Post, Hayriye Cagnan, Sooyoon Shin, Max A. Little, Yordan P. Raykov, Bastiaan R. Bloem, Rick C. Helmich, Luc J.W. Evers   +10 more
wiley   +1 more source

Motor, Extrapyramidal, and Cognitive Involvement in RFC1 Disease: A Systematic Review and Meta-Analysis. [PDF]

Neurol Genet
Massucco S, Hamedani M, Ponzano M, Manca R, Roveta E, Pichiecchio A, Asteggiano C, Zaottini F, Malaquias MJ, Currò R, Pardini M, Schenone A, Massa F, Cortese A, Grandis M.   +14 more
europepmc   +1 more source

Persistent negative symptoms in the EULAST cohort: impact on functional outcome. [PDF]

Schizophrenia (Heidelb)
Giuliani L, Pezzella P, Giordano GM, Perrottelli A, Mucci A, Bucci P, Bitter I, Arango C, Luykx JJ, Díaz-Caneja CM, Ebdrup BH, Davidson M, Tiihonen J, Winter-van Rossum I, Galderisi S.   +14 more
europepmc   +1 more source

Combined Striatal Dopaminergic and Cardiac Sympathetic Imaging in Parkinson's Disease. [PDF]

Brain Sci
Versweyveld L, Vanderlinden G, Vandenberghe W, Delva A, Van Laere K.   +4 more
europepmc   +1 more source