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Parkinson's Disease and Parkinsonism

The American Journal of Medicine, 2019
Parkinson's disease is a progressive neurodegenerative disease characterized by tremor and bradykinesia and is a common neurologic ailment. Male sex and advancing age are independent risk factors and, as the population ages, is taking an increasing toll on productivity and medical resources.
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Genetics of Parkinson's disease and parkinsonism

Annals of Neurology, 2006
AbstractUntil 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1‐PARK12 (OMIM 168600).
John, Hardy, Huaiban, Cai, Mark R, Cookson, Katrina, Gwinn-Hardy, Andrew, Singleton   +4 more
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Genetics of Parkinson’s disease and parkinsonism

Expert Review of Neurotherapeutics, 2007
The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased ...
Michael R, Douglas, Alistair J, Lewthwaite, David J, Nicholl   +2 more
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Identification of parkinsonism and Parkinson's disease

Drugs of Today, 2002
Parkinson's disease is a common movement disorder associated with considerable disability. The clinical syndrome of parkinsonism is based on the presence of core clinical features of rest tremor, bradykinesia, rigidity and impaired postural reflexes or gait.
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James Parkinson: Parkinson's Disease

Journal of Perioperative Practice, 2013
Parkinson's disease is a condition that anyone with a modicum of medical knowledge can recognise in the street - as indeed how it was studied by James Parkinson himself. Its three characteristic features are: 1. Increase in the tone of the voluntary muscles (rigidity). 2. Slowness of movement (bradykinesis).
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Sphingolipids in the Pathogenesis of Parkinson’s Disease and Parkinsonism

Trends in Endocrinology & Metabolism, 2019
The pathogenic mechanisms underlying Parkinson's disease (PD)/parkinsonism affect mitochondrial and endolysosomal trafficking. The retromer is required to retrieve some proteins from endosomes to the Golgi and plasma membrane. Here, we discuss how retromer-dependent retrieval also affects ceramide metabolism.
Guang, Lin, Liping, Wang, Paul C, Marcogliese, Hugo J, Bellen   +3 more
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Risk tables for parkinsonism and Parkinson's disease

Journal of Clinical Epidemiology, 2002
We applied the incidence rates of parkinsonism and Parkinson's disease (PD) from Olmsted County, MN (1976-1990) to a hypothetical cohort undergoing the mortality rates observed in Minnesota, and computed the lifetime risk and the remaining lifetime risk of developing parkinsonism and PD.
Alexis, Elbaz, James H, Bower, Demetrius M, Maraganore, Shannon K, McDonnell, Brett J, Peterson, J Eric, Ahlskog, Daniel J, Schaid, Walter A, Rocca   +7 more
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Functional Connectome in Parkinson’s Disease and Parkinsonism

Current Neurology and Neuroscience Reports, 2021
There has been an exponential growth in functional connectomics research in neurodegenerative disorders. This review summarizes the recent findings and limitations of the field in Parkinson's disease (PD) and atypical parkinsonian syndromes.Increasingly more sophisticated methods ranging from seed-based to network and whole-brain dynamic functional ...
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Neuroimaging of Parkinson’s disease and atypical parkinsonism

Current Neurology and Neuroscience Reports, 2004
The basal ganglia and its associated circuitry can be assessed with a variety of neuroimaging methods that can provide information regarding specific neurotransmitter systems, the functional activity of brain regions, and the structural integrity of these regions.
Dennis J, Zgaljardic, Andrew, Feigin
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Cardiac abnormalities in Parkinson’s disease and Parkinsonism

Journal of Clinical Neuroscience, 2018
Though there is increasing evidence for primary cardiac disease in Parkinson's disease (PD) and Parkinsonism (PS), this evidence is hardly included in the general management of these patients.Literature review.PD is one of the most common age-related neurodegenerative disorders. Epidemiological studies have shown that PD is accompanied by high rates of
Fulvio A, Scorza, Ana C, Fiorini, Carla A, Scorza, Josef, Finsterer   +3 more
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