Results 241 to 250 of about 450,934 (396)

Vascular Parkinsonism: Deconstructing a Syndrome

open access: yesMovement Disorders, 2015
Joaquin A. Vizcarra   +3 more
semanticscholar   +1 more source

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

open access: yesAdvanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox   +9 more
wiley   +1 more source

Toward Biology-Driven Diagnosis of Atypical Parkinsonian Disorders. [PDF]

open access: yesNeuroSci
Arias-Carrión O   +2 more
europepmc   +1 more source

L-dopa and cerebrospinal fluid homovanillic acid in parkinsonism

open access: bronze, 1969
William J. Weiner   +2 more
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

open access: yesAdvanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi   +10 more
wiley   +1 more source

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