Results 51 to 60 of about 127,921 (347)

Parkinson’s Disease Subtypes: Critical Appraisal and Recommendations

, 2021
Background: In Parkinson’s disease (PD), there is heterogeneity in the clinical presentation and underlying biology. Research on PD subtypes aims to understand this heterogeneity with potential contribution for the knowledge of disease pathophysiology ...
Berg, Daniela, Espay, AJ, Halliday, G, Erro, R, Fereshtehnejad, Seyed-Mohammad, Dujardin, K, Bohnen, Nicolaas I., Hu, MT, Erro, Roberto, Halliday, Glenda, Dujardin, Kathy, Mestre, TA, Berg, D, Mestre, Tiago A., Bohnen, NI, van, Hilten JJ, Espay, Alberto J., van Hilten, Jacobus J., Marras, Connie, Fereshtehnejad, S-M   +19 more
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Initiation of Levodopa-Carbidopa Intestinal Gel Infusion Using Telemedicine (Video Communication System) Facilitates Efficient and Well-Accepted Home Titration in Patients with Advanced Parkinsons Disease

, 2017
Background: Levodopa-carbidopa intestinal gel (LCIG; Duodopa r) is used for continuous infusion in advanced Parkinsons disease. To achieve optimal effect, the LCIG dose is individually titrated, traditionally conducted during hospitalization in Sweden ...
Urbom, Anna,, Anna Urbom, Kristina Groth, Permert, J, Kjellander, Susanna, Nil Dizdar, Permert, Johan, Dizdar Segrell, Nil,, Widner, H, Dizdar, Nil, Dizdar Segrell, Nil, Nyholm, Dag,, Widner, Hakan,, Larsson, Jorgen, Håkan Widner, Nyholm, Dag, Susanna Kjellander, Grenholm, Peter, Grenholm, P, Urbom, A, Kjellander, Susanna,, Grenholm, Peter,, Urbom, Anna, Larsson, J, Jörgen Larsson, Nyholm, D, Ursula Schmiauke, Groth, K, Groth, Kristina,, Permert, Johan,, Dizdar, N, Schmiauke, U, Willows, Thomas,, Dag Nyholm, Johan Permert, Thomas Willows, Schmiauke, Ursula,, Larsson, Jorgen,, Willows, T, Schmiauke, Ursula, Groth, Kristina, Willows, Thomas, Widner, Hakan, Peter Grenholm   +43 more
core   +1 more source

Cortex-wide topography of 1/f-exponent in Parkinson’s disease

, 2023
Parkinson's disease (PD) is a progressive and debilitating brain disorder. Besides the characteristic movement-related symptoms, the disease also causes decline in sensory and cognitive processing.
Kumar, A, Lundqvist, Daniel,, Vinding, Mikkel C. C.,, Vinding, MCC, Daniel Lundqvist, Pascal Helson, Arvind Kumar, Helson, Pascal,, Lundqvist, D,, Per Svenningsson, Helson, P, Svenningsson, P,, Mikkel C. Vinding, Svenningsson, Per,, Kumar, Arvind,   +14 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

The endocannabinoid signaling system and new experimental approaches to the treatment of movement disorders

Анналы клинической и экспериментальной неврологии, 2017
Reviewed are modern concepts concerning physiological role and mechanisms of brain functioning of the endocannabinoid signaling system comprising cannabinoid receptors, endocannabinoids and proteins participating in their synthesis, transport and ...
V. P. Barkhatova
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Nigrostriatal tau pathology in parkinsonism and Parkinsons disease. [PDF]

While Parkinsons disease remains clinically defined by cardinal motor symptoms resulting from nigrostriatal degeneration, it is now appreciated that the disease commonly consists of multiple pathologies, but it is unclear where these co-pathologies occur
Hirst, Warren, Harms, Ashley, Chu, Yaping, Federoff, Howard, Stoessl, A, Kordower, Jeffrey   +5 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Knowledge map of artificial intelligence in neurodegenerative diseases: a decade-long bibliometric and visualization study

Frontiers in Aging Neuroscience
BackgroundAs the incidence of neurodegenerative diseases increases, the related AI research is getting more and more advanced. In this study, we analyze the literature in this field over the last decade through bibliometric and visualization methods with
Junwei Huang, Shuqi Wang, Xuankai Liao, Danting Su, Rubing Lin, Tao Zhang, Long Zhao   +6 more
doaj   +1 more source