Results 51 to 60 of about 935,385 (269)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The1997 Scottish referendum : an analysis of the Scottish referendum [PDF]
, 1988 Referendums are rare events in the United Kingdom. Only one UK-wide referendum has been held - on membership of the European Community (as it then was) in 1975 - and before 1997 there had been only three other significant referendums: in 1973, in ...
Bochel, H. +3 more
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Scrutinising the secret state: parliamentary oversight of the intelligence and security agencies [PDF]
, 2010 This article considers the growing parliamentary scrutiny of the intelligence and security agencies. It raises a number of questions about the role and effectiveness of the Intelligence and Security Committee, Parliament and ...
Bochel, Hugh +2 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
The Scottish Parliament and the monarchy in the context of the monarchy and the Anglo-Scottish dynastic union, 1603-1707 [PDF]
, 2009 This journal article depicts the Scottish Parliament and the monarchy in the context of the monarchy and the Anglo-Scottish dynastic union, 1603 ...
Young, John R.
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Клиническая и специальная психология, 2015 The article is devoted to the study of the relationship between man and the space around him, namely between the patient and hospital environment. The article gives a little insight into the history of the issue.
Agalarova K.N.
doaj
Ekonomika, 2020 The article aims at ascertaining the relationship between indicators affecting the green economic growth of the Eurozone countries. Despite extensive research, scientists have not yet found a clear answer as to whether economic growth and climate change ...
Violeta Klyviene, Angele Kedaitiene
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source