Results 61 to 70 of about 72,996 (238)
Conflict without an Apparent Cause
Games, 2019 A game-theoretic model of repeated interaction between two potential adversaries is analyzed to illustrate how conflict could possibly arise from rational decision-makers endogenously processing information, without any exogenous changes to the ...
Timothy Mathews, Aniruddha Bagchi
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A Tale of Two Serbias? Census-taking in 2002 and 2011
Contemporary Southeastern Europe, 2015 The challenges implicit in census-taking are especially pronounced in the Western Balkans and, very specifically, in Serbia, considering this country’s multi-ethnic and multi-religious makeup, as reflected in territorial delineations, as well as its ...
Mina Djurić Nikolić, Laura Trimajova
doaj
ANALYSIS OF SURVIVAL STRATEGIES OF SPECIES ALLIUM L. IN THE RUSSIAN CAUCASUS
Юг России: экология, развитие, 2016 The aim. The main objective of this work is to analyze the survival strategies of 20 species of the Allium genus in the Russian part of the Caucasus (Kabardino-Balkaria, Karachay-Cherkessia, North Ossetia, Ingushetia and Dagestan).Methods.
V. A. Chadaeva, S. H. Shhagapsoev
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source