Bilateral Investment Treaties of Uzbekistan: Investor-State Dispute Resolution
University of Bologna Law Review, 2019 The main purpose of this paper is to familiarise the reader with how foreign investors are protected in Uzbekistan under its BITs. Thus, the paper will analyse BIT clauses of Uzbekistan and investor-state dispute resolution mechanisms available under ...
Eldor Tulyakov
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
South Africa in international perspective
South African Journal of Business Management, 1979 Adress delivered at an economic seminar on South Africa on 20 June 1979 at Palm Springs, California, USA.
Jan S. Marais
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Debates of the First Session of the First Parliament of the House of Assembly 1910-1911 [PDF]
, 1910 First Parliament, First Session, 1910/11-Fourth Session, 1914.Debates of the House of Assembly of the Union of South Africa, as reported in the Cape Times.
South Africa Parliament
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Union of South Africa. House of Assembly. Debates of the Second Session of the First Parliament 1912 [PDF]
, 1912 First Parliament, First Session, 1910/11-Fourth Session, 1914.Debates of the House of Assembly of the Union of South Africa, as reported in the Cape Times. Debates / South Africa. Parliament.
South Africa Parliament
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Union of South Africa. Debates of the House of Assembly. Fourth Session Fourth Parliament 1924 [PDF]
, 1924 Fourth Session, 4th Parliament, vol. 1 (25 Jan.-10 Apr. 1924)-4th Session, 12th Parliament, v. 108 (1 May-26 May 1961). Vol. 1 of this series published parallel with the Dutch title: Debatten van de Volksraad.Debates of the House of Assembly of the ...
South Africa Parliament
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