Results 51 to 60 of about 939,925 (287)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The macroeconomic consequences of Scottish fiscal autonomy: inverted haavelemo effects in a general equilibrium analysis of the tartan tax [PDF]

open access: yes, 2007
In 1997 the Scottish people voted both for the creation of a legislative Parliament and to endow the Parliament with tax-varying powers. The establishment of the Scottish Parliament in 2000 heralded the most radical innovation in the regional fiscal ...
McGregor, Peter G.   +2 more
core  

English funding of the Scottish armies in England and Ireland 1640-1648 [PDF]

open access: yes, 2009
The rebellion against Charles I's authority that began in Edinburgh in 1637 involved the Scots in successive invasions of England and armed intervention in Ireland. Historians have almost universally taken a negative view of Scottish involvement in these
Stewart, Laura A.M.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Subjective Factors of the Hospital Environment and Their Influence on Psychological Well-being of Patients

open access: yesКлиническая и специальная психология, 2015
The article is devoted to the study of the relationship between man and the space around him, namely between the patient and hospital environment. The article gives a little insight into the history of the issue.
Agalarova K.N.
doaj  

Electing a parliament [PDF]

open access: yes, 2007
We present a model where a society elects a parliament by voting for candidates belonging to two parties. The electoral rule determines the seats distribution between the two parties.
De Sinopoli, Francesco   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

South Africa in international perspective

open access: yesSouth African Journal of Business Management, 1979
Adress delivered at an economic seminar on South Africa on 20 June 1979 at Palm Springs, California, USA.
Jan S. Marais
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

The The Relationships between Economic growth, Energy Efficiency and CO2 Emissions: Results for the Euro Area

open access: yesEkonomika, 2020
The article aims at ascertaining the relationship between indicators affecting the green economic growth of the Eurozone countries. Despite extensive research, scientists have not yet found a clear answer as to whether economic growth and climate change ...
Violeta Klyviene, Angele Kedaitiene
doaj   +1 more source

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