Results 61 to 70 of about 913,370 (314)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Geleitwort zur Konferenz „Vielfalt und Demokratie – Identitätssuche in unübersichtlichen Zeiten“

open access: yesInternational Dialogues on Education: Past and Present, 2016
Prof. Dr. Dr. h.c. mult. Rita Süßmuth, Präsidentin des Deutschen Bundestages a.D.
Rita Süßmuth
doaj   +1 more source

Designing an institutional network for improving farm animal welfare in the EU [PDF]

open access: yes, 2017
Improvements in the welfare of farmed animals in the EU have been achieved by legislation, increased welfare capacity in the food chain, greater public awareness, welfare measurement tools and dissemination of best practice.
Aguilar   +18 more
core   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

Conflict without an Apparent Cause

open access: yesGames, 2019
A game-theoretic model of repeated interaction between two potential adversaries is analyzed to illustrate how conflict could possibly arise from rational decision-makers endogenously processing information, without any exogenous changes to the ...
Timothy Mathews, Aniruddha Bagchi
doaj   +1 more source

The evaluative role of legislatures in creating a responsive executive

open access: yesAfrican Evaluation Journal, 2020
The ability of legislatures to play a more effective oversight role is intricately linked to its ability to properly conceptualise and institutionalise its monitoring and evaluation (ME) function.
Reitumetse Zantsi
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

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