Results 211 to 220 of about 15,613 (254)
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Paroxysmal Nocturnal Hemoglobinuria
Nederlands tijdschrift voor geneeskunde, 1992Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder of the hematopoietic stem cell (Hartmann and Arnold 1977) resulting in the production of blood cells which are defective in that they lack or are markedly deficient in glycan-phosphatidylinositol (GPI)-linked surface proteins (Rosse 1990a).
T W, Huizinga +3 more
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Paroxysmal Nocturnal Hemoglobinuria
Journal of Computer Assisted Tomography, 1993Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disorder, characterized by hemosiderin deposition in the proximal renal tubules.We examined six cases of PNH with MRI including gradient echo imaging.On T2- and T2*-weighted imaging a characteristic hypointense pattern was noted in five of six patients with PNH.
Y O, Tanaka, I, Anno, Y, Itai, T, Abe
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Paroxysmal Nocturnal Hemoglobinuria Revisited
New England Journal of Medicine, 1983Immunologic systems are now known to have a major role in the pathophysiology of many human disease processes. One such system is serum complement.
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Paroxysmal Nocturnal Hemoglobinuria in Children
Pediatric Drugs, 2007Paroxysmal nocturnal hemoglobinuria (PNH), an acquired hematologic disorder characterized by intravascular hemolysis, nocturnal hemoglobinuria, thrombotic events, serious infections, and bone marrow failure, is very rare in children. PNH is caused by a somatic mutation of the phosphatidylinositol glycan (GPI) complementation class A (PIGA) gene ...
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Paroxysmal Nocturnal Hemoglobinuria
New England Journal of Medicine, 1952THE most accurate method of study of any disease is enlightened statistical analysis of a large number of cases. However, paroxysmal nocturnal hemoglobinuria is a rare blood dyscrasia; approximately 45 cases, not all of convincing authenticity, have appeared in the literature to this time.9 Consequently, no physician or group of physicians is likely to
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Paroxysmal Nocturnal Hemoglobinuria
New England Journal of Medicine, 1961PAROXYSMAL nocturnal hemoglobinuria is a disease with a fascinating diversity of challenges and implications. These have prompted numerous clinical and basic investigations. The clinical features are often bizarre and may be misleading, even with the most typical presentation of abdominal pain, fatigue, weakness, anemia and dark urine and with venous ...
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Paroxysmal Nocturnal Hemoglobinuria
A.M.A. Archives of Internal Medicine, 1957Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic disease of insidious onset and chronic course, characterized by an intracorpuscular erythrocytic defect rendering the cells unusually susceptible to hemolysis in vitro and probably in vivo upon slight acidification of the plasma. The constant feature of the disease is hemosiderinuria, rather
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[Paroxysmal nocturnal hemoglobinuria].
La Revue du praticien, 2007Paroxysmal nocturnal haemoglobinuria is a rare clonal disease of the hematopoietic stem cell. Since the 80's considerable advances in the biology of this rare disease have been done. The pathophysiology, recent advances in the diagnosis and treatment of this disease are reviewed, pointing out, however, the yet unanswered question with regard to the ...
Régis, Peffault de Latour +1 more
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[Paroxysmal nocturnal hemoglobinuria].
Klinische Wochenschrift, 1990Paroxysmal nocturnal hemoglobinuria, first described in the late 19th century, is an acquired disorder characterized by hemoglobinemia and hemoglobinuria. The major clinical manifestation of PNH is chronic intravascular hemolysis of various severity. Patients-mostly young adults - may also present with episodes of abdominal or back pain.
P, Blaas +3 more
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Paroxysmal Nocturnal Hemoglobinuria
Laboratory Medicine, 1994This article, the fourth in a continuing education update series on hematology, reviews paroxysmal nocturnal hemoglobinuria (PNH), a clonal marrow stem cell disorder that involves erythroid, myeloid, megakaryocytic, and some lymphoid lineage. The disorder is sometimes classified as a chronic myeloproliferative syndrome because of its potential to ...
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