Results 91 to 100 of about 25,426 (206)

Epacadostat and Olaparib Synergistically Inhibit the Growth of BRCA-Proficient Triple-Negative Breast Cancer by Suppressing the Expression of BRCA1 and RAD51

Molecules
Triple-negative breast cancer (TNBC) cells with intact homologous recombination (HR) repair mechanism can survive treatment with Olaparib, which further limits the clinical application of PARP1/2 inhibitors.
Lei Huang, Ye Yang, Dongxia Duan, Li Dai, Bingxin Zhai, Bingjun Qian   +5 more
doaj   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted therapies remain ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source

Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks

Nature Communications
Poly(ADP-ribose) polymerase 1 (PARP1) detects DNA strand breaks that occur in duplex DNA and chromatin. Here, correlative optical tweezers and fluorescence microscopy reveal how single molecules of PARP1 identify single-strand breaks (i.e., nicks ...
Matthew A. Schaich, Tyler M. Weaver, Jennifer A. Rakowski, Vera Roginskaya, Liam P. Leary, Aafke A. Van den Berg, Janet H. Iwasa, Bret D. Freudenthal, Bennett Van Houten   +8 more
doaj   +1 more source

The TRPM2–PARP‐1 Axis Involvement in Bisphenol A and Nonylphenol‐Induced Ferroptosis in Trigeminal Ganglion Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan, Musa Tatar, Yener Yazğan, Kıymet Kübra Tüfekci   +3 more
wiley   +1 more source

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

Understanding roles for PARP1 in skeletal muscle [PDF]

, 2023
Depletion of Nicotinamide adenine dinucleotide (NAD+), a critical cofactor in biochemical reactions, is ascribed to metabolic dysfunction and poor quality of life.
Tan, A
core  

Serine-linked PARP1 auto-modification controls PARP inhibitor response.

, 2021
Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated by DNA damage, resulting in ADP-ribosylation at numerous sites, both within PARP1 itself and in other proteins.
Kira Schützenhofer, Ian Gibbs-Seymour, Dragana Ahel, Groslambert, Joséphine, John Brognard, Evgeniia Prokhorova, Suskiewicz, Marcin J., Thomas Agnew, Rebecca Smith, Florian Zobel, Ahel, Dragana, Prokhorova, Evgeniia, Zentout, Siham, Sébastien Huet, Zobel, Florian, Alessandra Peters, Marcin J. Suskiewicz, Valentina Zorzini, Michael L. Nielsen, Smith, Rebecca, Brognard, John, Gibbs-Seymour, Ian, Peters, Alessandra, Zorzini, Valentina, Ivan Ahel, Siham Zentout, Schützenhofer, Kira, Huet, Sébastien, Ahel, Ivan, Joséphine Groslambert, Suskiewicz, Marcin J, Nielsen, Michael L, Agnew, Thomas, Nielsen, Michael L.   +33 more
core   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer

Redox Biology, 2018
PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful.
Dong Hou, Zhaojian Liu, Xiuhua Xu, Qiao Liu, Xiyu Zhang, Beihua Kong, Jian-Jun Wei, Yaoqin Gong, Changshun Shao   +8 more
doaj   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source