Results 71 to 80 of about 25,426 (206)

FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Nature Communications
The effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ DNA helicase. Yet, how FANCJ relates to PARP1 inhibition or trapping, which contribute to PARPi toxicity,
Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G. MacLeod, Jennifer Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A. Day, Sharon B. Cantor   +8 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Upregulated PARP1 confers breast cancer resistance to CDK4/6 inhibitors via YB-1 phosphorylation

Experimental Hematology & Oncology, 2023
Background Cyclic-dependent kinase (CDK) 4/6 kinases, as the critical drivers of the cell cycle, are involved in the tumor progression of various malignancies.
Chuntao Quan, Zhijie Wu, Juan Xiong, Manqing Li, Yu Fu, Jiaying Su, Yue Wang, Lvwen Ning, Deju Zhang, Ni Xie   +9 more
doaj   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Analisi in silico della doxiciclina come inibitore della PARP1 nella terapia dell'Alzheimer

, 2023
LAUREA MAGISTRALELa PARP1 (Poly-ADP ribose polymerase-1) è un enzima coinvolto nella riparazione del DNA danneggiato e nei processi infiammatori. Studi recenti hanno suggerito che l'attivazione eccessiva della PARP1 nel cervello degli individui affetti ...
STRATI, SARA
core  

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Exploring the interaction of G-quadruplex binders as an alternative approach to PARP1 inhibition

, 2022
PARP1 is a nuclear enzyme involved in DNA repair processes. Since its inhibition causes sensitization to DNA damaging chemotherapy (the so-called “synthetic lethality”), several inhibitors have been recently developed and exploited for clinical use ...
Artali, R., Musso, L., Princiotto, S., Gargallo, R., Mazzini, S., Aviñó, A., Dallavalle, S, Eritja, R.   +7 more
core  

PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models [PDF]

, 2017
Background: Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline alkylating agent with a peculiar mechanism of action.
Annalisa Lorenzato, Napione, Lucia, Marco Basiricò, Francesca Vignolo Lutati, Giovanni Grignani, Basiricò, Marco, Chiabotto, Giulia, Pignochino, Ymera, Dell'Aglio, Carmine, Sandra Aliberti, Loretta Gammaitoni, Dario Sangiolo, Canta, Marta, Boccone, Paola, Miano, Sara, Massimo Aglietta, Erica Palesandro, Maria Serena Benassi, Gammaitoni, Loretta, Sangiolo, Dario, Aliberti, Sandra, Sara Miano, Galizia, Danilo, Palesandro, Erica, Grignani, Giovanni, Giulia Chiabotto, Lorenzato, Annalisa, Chiorino, Giovanna, Ymera Pignochino, Carmine Dell’Aglio, Paola Boccone, Lucia Napione, D'Ambrosio, Lorenzo, Federica Capozzi, Barbara Pasini, Danilo Galizia, Vignolo Lutati, Francesca, Benassi, Maria Serena, Aglietta, Massimo, Marta Canta, Capozzi, Federica, Pasini, Barbara, Giovanna Chiorino, Lorenzo D’Ambrosio   +43 more
core   +1 more source