Results 51 to 60 of about 25,426 (206)

Supplementary Figures from Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G₂ DNA Damage Checkpoint

, 2020
Figure S1. Synthetic lethality between ATM loss and PARP1 inhibition. Figure S2. Synergism between inhibitors of ATM and PARP1 occurs in multiple cell lines and with different inhibitors. Figure S3.
Randy Y.C. Poon (15085218), Joyce P.Y. Mak (15085212), Hoi Tang Ma (15085215)   +2 more
core   +1 more source

PARP1 promotes the progression of hepatocellular carcinoma by regulating expression of POU2F2 [PDF]

Zhongguo aizheng zazhi
Background and purpose: Hepatocellular carcinoma (HCC) is a major disease seriously threatening human health. Poly (ADP-ribose) polymerase-1 (PARP1) is an enzyme that catalyzes poly ADP-ribosylation.
WEN Ziqiang, LAN Junliang, ZHOU Bo, XU Qiwei
doaj   +3 more sources

Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest [PDF]

Cancer Research, 2016
Abstract Although hyperthermia offers clinical appeal to sensitize cells to chemotherapy, this approach has been limited in terms of long-term outcome as well as economic and technical burden. Thus, a more detailed knowledge about how hyperthermia exerts its effects on chemotherapy may illuminate ways to improve the approach. Here, we
Lea, Schaaf, Matthias, Schwab, Christoph, Ulmer, Simon, Heine, Thomas E, Mürdter, Jens O, Schmid, Georg, Sauer, Walter E, Aulitzky, Heiko, van der Kuip   +8 more
openaire   +2 more sources

PARP1 is required for adhesion molecule expression in atherogenesis [PDF]

, 2008
AIMS: Atherosclerosis is the leading cause of death in Western societies and a chronic inflammatory disease. However, the key mediators linking recruitment of inflammatory cells to atherogenesis remain poorly defined. Poly(ADP-ribose) polymerase 1 (PARP1)
Mach, François, Stähli, Barbara E; https://orcid.org/, Stähli, Barbara E, Camici, Giovanni G., Hottiger, Michael O., Hassa, Paul O, Matter, Christian M., Matter, Christian M; https://orcid.org/, Gersbach, Monika, Odermatt, Bernhard, Tanner, Felix C., Hottiger, Michael O; https://orcid.org/, Hassa, Paul O., Stähli, Barbara E., Lüscher, Thomas F, Lüscher, Thomas F., Tanner, Felix C, Tanner, Felix C; https://orcid.org/, Borén, Jan, Hottiger, Michael O, Camici, Giovanni G, Matter, Christian M, Borén, Jan,, von Lukowicz, Tobias, Braunersreuther, Vincent, Lohmann, Christine, Lüscher, Thomas F; https://orcid.org/, Mach, François; https://orcid.org/, Camici, Giovanni G; https://orcid.org/   +28 more
core   +1 more source

FTO suppresses DNA repair by inhibiting PARP1

Nature Communications
Maintaining genomic integrity and faithful transmission of genetic information is essential for the survival and proliferation of cells and organisms. DNA damage, which threatens the integrity of the genome, is rapidly sensed and repaired by mechanisms collectively known as the DNA damage response.
Tianyi Zhu, Jing Zhi Anson Tan, Lingrui Zhang, He Huang, Sooraj S. Das, Flora Cheng, Pranesh Padmanabhan, Mathew J. K. Jones, Mihwa Lee, Albert Lee, Jocelyn Widagdo, Victor Anggono   +11 more
openaire   +5 more sources

Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition

Cellular Oncology, 2017
The identification of novel therapeutic targets that exploit the aberrant genetics driving oncogenesis is critical to better combat cancer. RNF20 is somatically altered in numerous cancers, and its diminished expression drives genome instability, a driving factor of oncogenesis. Accordingly, we sought to determine whether PARP1 silencing and inhibition
Brent J. Guppy, Kirk J. McManus
openaire   +2 more sources

Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells

Translational Oncology
The preference of cancer cells to generate energy from glycolysis for rapid cell proliferation is called the Warburg effect. Poly(ADP-ribose) polymerase 1 (PARP1) performs various cellular functions, including poly-ADP-ribosylation and DNA repair. In the
Chenxuan Zhang, Peng Wang, Jia Yu, Jianhui Yuan, Lilong Zhang, Man Li   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source