Results 41 to 50 of about 25,426 (206)
, 2020 Trauma is the main cause of death for people aged 1-45, and among them, traumatic brain injury (TBI) is the major condition, which causes over 50,000 deaths each year and costs over 80 billion per year.
Yu Chen +4 more
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The Role of PARP1 and PARP Inhibition in Tuberculosis [PDF]
, 2021 Tuberculosis (TB) is a devastating infectious disease that is challenging to treat and responsible for over a million human deaths every year. TB elicits a multifaceted host response that can contain the infection at the cost of inflammation, tissue ...
Krug, Stefanie
core
PARP1 inhibition enhances in vitro induced-oxidative damage in human neural models
, 2023 A poli (ADP-ribose) polimerase 1 (PARP1) é uma enzima com múltiplas funções celulares, predominantemente ativada por danos no DNA. A superexpressão de PARP1 tem sido associada a diversos distúrbios neurodegenerativos e o papel do estresse oxidativo tem ...
Piassi, Larissa de Oliveira
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PARP1 Represses PAP and Inhibits Polyadenylation during Heat Shock [PDF]
Molecular Cell, 2013 The 3' ends of most eukaryotic mRNAs are produced by an endonucleolytic cleavage followed by synthesis of a poly(A) tail. Poly(A) polymerase (PAP), the enzyme that catalyzes the formation of the tail, is subject to tight regulation involving several posttranslational modifications.
Di Giammartino, Dafne Campigli +2 more
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Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth
Cell Communication and Signaling, 2022 Background Targeting AKT suppresses tumor growth through inducing apoptosis, however, during which whether other forms of cell death occurring is poorly understood.
Yizheng Zhang +11 more
doaj +1 more source
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
eLife, 2020 It is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi possess both PARP1 inhibition and PARP1 trapping activities.
Chiho Kim, Xu-Dong Wang, Yonghao Yu
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Frontiers in Cellular Neuroscience, 2015 Poly(ADP-ribose) polymerase-1 (PARP1) plays a regulatory role in apoptosis, necrosis, and other cellular processes after injury. Recently, we revealed that PARP1 regulates the differential neuronal/astroglial responses to pilocarpine-induced status ...
Ji Yang eKim, Ah-Reum eKo, Ji-Eun eKim
doaj +1 more source
Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma
Haematologica, 2020 Multiple Myeloma (MM) is a hematologic malignancy strongly characterized by genomic instability, which promotes disease progression and drug resistance.
Daniele Caracciolo +16 more
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Redox Biology, 2018 Hallmarks of cancer cells include uncontrolled growth and rapid proliferation; thus, cyclin-dependent kinases are a therapeutic target for cancer treatment.
Dominika Tempka +7 more
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XRN2 Depletion is Synthetic Lethal with PARP1 Inhibition
The FASEB Journal, 2019 Persistent R‐loops (RNA‐DNA hybrids with a displaced single‐stranded DNA) create DNA damage and lead to genomic instability. The 5’‐3’‐exoribonuclease 2 (XRN2) degrades RNA to resolve R‐loops and promotes transcription termination. Previously, XRN2 was implicated in DNA double strand break (DSB) repair and in resolving replication stress. XRN2 function
Louise Pay +10 more
openaire +1 more source