Results 21 to 30 of about 25,426 (206)

Functional Aspects of PARP1 in DNA Repair and Transcription

Biomolecules, 2012
Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus achieves synthetic lethality by preventing unwanted DNA repair in the ...
Hui Ling Ko, Ee Chee Ren
doaj   +2 more sources

PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory Response and Cardiac Function. [PDF]

J Am Coll Surg, 2023
BACKGROUND: Burn injury induces multiple signaling pathways leading to a significant inflammatory storm that adversely affects multiple organs, including the heart. Poly (ADP-ribose) polymerase inhibitor 1 (PARP1) inhibition, with specific agents such as N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide (PJ34), is effective ...
Wen JJ, Dejesus JE, Radhakrishnan GL, Radhakrishnan RS.   +3 more
europepmc   +3 more sources

Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition. [PDF]

Cancer Chemother Pharmacol, 2017
Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have somatic inactivating mutations in the BAP1 gene.
Srinivasan G, Sidhu GS, Williamson EA, Jaiswal AS, Najmunnisa N, Wilcoxen K, Jones D, George TJ, Hromas R.   +8 more
europepmc   +4 more sources

PARP1: Structural insights and pharmacological targets for inhibition

DNA Repair, 2021
Poly(ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base excision repair (BER), non-homologous end joining (NHEJ), homologous recombination (HR), and Okazaki-fragment processing pathways.
Jacob O. Spiegel, Bennett Van Houten, Jacob D. Durrant   +2 more
openaire   +2 more sources

Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition. [PDF]

Cancers (Basel), 2021
Centromere Protein I (CENP-I) is a member of the CENP-H/I/K complex. CENP-H/I/K is a major component of the inner kinetochore and aids in ensuring proper chromosomal segregation during mitosis. In addition to this chromosomal segregation function, CENP-I also plays a role in DNA double-strand break (DSB) repair.
Dang TT, Morales JC.
europepmc   +4 more sources

PARP1 Inhibition as a Novel Therapeutic Target for Keloid Disease. [PDF]

Adv Wound Care (New Rochelle), 2019
Objective: Inactivation of poly(ADP-ribose) polymerase 1 ( PARP1 ) has been found to have protective effect in several fibrotic diseases. But the effect is not studied yet in keloids. Herein, we evaluated the therapeutic effect of
Park TH, Kim CW, Choi JS, Park YJ, Chong Y, Park MJ, Cho Y.   +6 more
europepmc   +4 more sources

PARP inhibition: PARP1 and beyond [PDF]

Nature Reviews Cancer, 2010
Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide ...
Michèle, Rouleau, Anand, Patel, Michael J, Hendzel, Scott H, Kaufmann, Guy G, Poirier   +4 more
openaire   +2 more sources

Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation

Scientific Reports, 2022
Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β cell death ...
Nidheesh Dadheech, Abhay Srivastava, Rashmi G. Shah, Girish M. Shah, Sarita Gupta   +4 more
doaj   +1 more source

PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration

Ecotoxicology and Environmental Safety, 2023
Rotenone, a widely used pesticide, causes dopaminergic neurons loss and increase the risk of Parkinson's disease (PD). However, few studies link the role of PARP1 to neuroinflammatory response and autophagy dysfunction in rotenone-induced ...
He Zhang, Zhefan Xie, Yongming Peng, Ailun Xie, Chunlai Fu, Dongyan Zheng, ZiWei Cai, Jiahong Zhong, Qiang Ming, Mingque Li, Renjian Lu, Xin Liu, Jialong Chen   +12 more
doaj   +1 more source

Poly ADP-Ribose Polymerase-1 inhibition by 3-aminobenzamide recuperates HEI-OC1 auditory hair cells from blast overpressure-induced cell death

Frontiers in Cell and Developmental Biology, 2023
Introduction: Poly ADP-Ribose Polymerase-1 (PARP1), a DNA repair enzyme is implicated as a key molecule in the pathogenesis of several neurodegenerative disorders.
Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Supriya D. Mahajan   +2 more
doaj   +1 more source