Results 1 to 10 of about 24,281 (106)

Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting [PDF]

Advanced Science, 2022
Poly (ADP‐ribose) polymerase 1 (PARP1) plays a fundamental role in DNA repair and gene expression. Excessive PARP1 hyperactivation, however, has been associated with cell death. PARP1 and/or its activity are dysregulated in the immune and central nervous
Yan Wang, David Pleasure, Wenbin Deng, Fuzheng Guo   +3 more
doaj   +3 more sources

Sp1 Targeted PARP1 Inhibition Protects Cardiomyocytes From Myocardial Ischemia–Reperfusion Injury via Downregulation of Autophagy [PDF]

Frontiers in Cell and Developmental Biology, 2021
Myocardial ischemia–reperfusion injury (MIRI), characterized by post-ischemic cardiomyocytes death and reperfusion myocardial damage, is a lethal yet unresolved complication in the treatment of acute myocardial infarction (AMI).
Yifeng Xu, Boqian Wang, Xiaoxiao Liu, Yunfei Deng, Yanqi Zhu, Feng Zhu, Yanyan Liang, Hongli Li   +7 more
doaj   +4 more sources

In Silico Investigation of the Molecular Mechanism of PARP1 Inhibition for the Treatment of BRCA-Deficient Cancers [PDF]

Molecules, 2023
The protein PARP1, which plays a crucial role in DNA repair processes, is an attractive target for cancer therapy, especially for BRCA-deficient cancers.
Fengqin Yan, Zhenfu Fu, Guo Li, Zhiguo Wang   +3 more
doaj   +4 more sources

PARP1 inhibition elicits immune responses against non-small cell lung cancer [PDF]

OncoImmunology, 2022
High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis.
Pan Juncheng, Antoine Lafarge, Guido Kroemer, Maria Castedo   +3 more
doaj   +2 more sources

PARP1 inhibition protects mice against Japanese encephalitis virus infection

Cell Reports, 2023
Summary: Japanese encephalitis (JE) is a vector-borne viral disease that causes acute encephalitis in children. Although vaccines have been developed against the JE virus (JEV), no effective antiviral therapy exists.
Perumal Arumugam Desingu, Sneha Mishra, Lavanya Dindi, Shalini Srinivasan, Raju S. Rajmani, Venkatraman Ravi, Ankit Kumar Tamta, Sukanya Raghu, Krishnega Murugasamy, Anwit Shriniwas Pandit, Nagalingam R. Sundaresan   +10 more
doaj   +3 more sources

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

Cell Reports
Summary: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin.
Petar-Bogomil Kanev, Sylvia Varhoshkova, Irina Georgieva, Maria Lukarska, Dilyana Kirova, Georgi Danovski, Stoyno Stoynov, Radoslav Aleksandrov   +7 more
doaj   +3 more sources

PARP1-Inhibition Sensitizes Cervical Cancer Cell Lines for Chemoradiation and Thermoradiation [PDF]

Cancers, 2021
Marloes Ijff, Gregor G W Van Bochove, Celina Honhoff   +2 more
exaly   +2 more sources

PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis [PDF]

Journal of Medical Virology
Davide Maestri, Paul M Lieberman, Italo Tempera   +2 more
exaly   +2 more sources

Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization Against PARP1 Inhibition in a Replication-Dependent Manner [PDF]

Cancers, 2020
Johanna Rieckhoff, Felix Meyer, Harriet Wikman   +2 more
exaly   +2 more sources

Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

Cell Stress, 2023
The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease.
Maria Castedo, Antoine Lafarge, Guido Kroemer   +2 more
doaj   +1 more source