Resveratrol Inhibits Nucleosome Binding and Catalytic Activity of PARP1
BiomoleculesThe natural polyphenol resveratrol is a biologically active compound that interacts with DNA and affects the activity of some nuclear enzymes. Its effect on the interaction between nucleosomes and poly(ADP-ribose) polymerase-1 (PARP1) and on the ...
Daria O. Koshkina +5 more
doaj +4 more sources
Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition. [PDF]
Cell Death Dis, 2021 Cervical cancer (CC) is the fourth most common cause of cancer-related death in women. According to international guidelines, a standard treatment for locally advanced cervical cancer (LACC) consists of exclusive concurrent chemoradiation treatment (CRT).
Raspaglio G +6 more
europepmc +7 more sources
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. [PDF]
Sci Rep, 2020 Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination.
Patidar PL +6 more
europepmc +5 more sources
PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease. [PDF]
PLoS Pathogens, 2020 Trypanosoma cruzi (T. cruzi) is the etiological agent of Chagas cardiomyopathy. In the present study, we investigated the role of extracellular vesicles (Ev) in shaping the macrophage (Mφ) response in progressive Chagas disease (CD). We purified T. cruzi
Subhadip Choudhuri, Nisha Jain Garg
doaj +2 more sources
Targeted Radiosensitization of ETS Fusion-Positive Prostate Cancer through PARP1 Inhibition
Neoplasia: An International Journal for Oncology Research, 2013 ETS gene fusions, which result in overexpression of an ETS transcription factor, are considered driving mutations in approximately half of all prostate cancers.
Sumin Han +9 more
doaj +2 more sources
Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes
Cells, 2022 Inhibitors (PARPi) of poly(ADP-ribose-)polymerase-1 (PARP1) are used in antitumor therapy; their cytotoxicity correlates with the efficiency of PARP1 trapping in cell chromatin.
Natalya Maluchenko +4 more
doaj +2 more sources
From PARP1 to TNKS2 inhibition: A structure-based approach
ACS Medicinal Chemistry Letters, 2020 Tankyrases (TNKSs) have recently gained great consideration as potential targets in Wnt/β-catenin pathway-dependent solid tumors. Previously, we reported the 2-mercaptoquinazolin-4-one MC2050 as a micromolar PARP1 inhibitor.
Tomassi S +25 more
core +8 more sources
Nature Communications, 2023 The antibiotic pyrazinamide (PZA) is a cornerstone of tuberculosis (TB) therapy that shortens treatment durations by several months despite being only weakly bactericidal.
Stefanie Krug +9 more
doaj +3 more sources
Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. [PDF]
PLoS ONE, 2016 Hyperglycemia and hypertension impair endothelial function in part through oxidative stress-activated poly (ADP-ribose) polymerase 1 (PARP1). Biguanides and angiotensin II receptor blockers (ARBs) such as metformin and telmisartan have a vascular ...
Fenqing Shang +12 more
doaj +3 more sources
PARP1 inhibition enhances reactive oxygen species on gut microbiota. [PDF]
J Cell Physiol, 2022 AbstractPoly(ADP‐ribose) polymerase 1 (PARP1) plays a key role in genome stability by modulating DNA‐damage responses. Activated by DNA interruptions through ultraviolet (UV) exposure, PARylation is synthesized by PARP1 and serves as a survival mechanism for cancer and metabolic diseases.
Zhuang Y +13 more
europepmc +3 more sources