Results 331 to 340 of about 3,443,356 (396)

Phytotherapeutic Regulation of Matrix Metalloproteinases in Diabetic Foot Ulcer: Molecular Mechanisms and Wound Healing Perspectives

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
Chronic inflammation in diabetic foot ulcers elevates MMP activity and suppresses TIMP and growth factor signaling, impairing tissue repair. Phytochemicals modulate NF‐κB/MAPK pathways and enhance Nrf2–TIMP expression, restoring MMP/TIMP balance, promoting collagen deposition, angiogenesis, and re‐epithelialization, leading to effective wound healing ...
Vishnu Priyan Elaiyaraja, Eswara Rajagopal, Subhikssha Babu, Balaji Sadhasivam   +3 more
wiley   +1 more source

DNA Methylation in Ovarian and Endometrial Cancers: Predictive and Mechanistic Roles in PARP Inhibitor and ICI Response. [PDF]

Cancer Sci
Kitamura S, Taguchi A, Tamai K, Yamamoto Y, Duong AQ, Yoshimoto D, Mori A, Ishizaka A, Tsuchimochi S, Sone K, Kawazu M, Oda K, Hirota Y.   +12 more
europepmc   +1 more source

DNA recognition, cleavage, and toxic metal ion interaction of an artificial zinc finger protein inside E. coli cells

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Zinc finger proteins are essential for the proper functioning of eukaryotic organisms, while their artificial variants can be used in cancer therapy or gene editing via their specific DNA recognition. Zn(II) binding is indispensable for the structural integrity of zinc fingers.
Bálint Hajdu, Annamária Tóth, Bettina Fazekas, Melinda Horvát, Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata, Attila Jancsó, Béla Gyurcsik   +8 more
wiley   +1 more source

Characterization of Parthanatos in Breast Cancer: Implications for Prognosis and PARP Inhibitor Resistance. [PDF]

Bioengineering (Basel)
Tang J, Liu Q, Du W, Chen L, Qi F, Zhang R, Hoang BH, Geller DS, Yang R, Wang J, Hu L.   +10 more
europepmc   +1 more source

CEACAM6: A potential prognostic biomarker and therapeutic target in cholangiocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Jia‐Qi Guo, Shi‐Jia Dai, Yang Liu, Zhen‐Gang Yuan   +3 more
wiley   +1 more source

Socioeconomic and Demographic Factors in Genetic Testing Utilization Among Advanced Prostate Cancer Patients

The Prostate, Volume 86, Issue 8, Page 941-948, June 2026.
ABSTRACT Purpose Germline genetic testing in patients with advanced prostate cancer (PCa) is underutilized and hypothesized to be impacted by socioeconomic and demographic factors. This single institution, retrospective study assessed the association of income and social vulnerability with genetic referrals and testing.
Alexandra T. Skowron, Karen Childers, Courtney M. Rose, Kyle C. McElyea, Avery K. Supernois, Yousuf Hussain, Mohammed Baseer, Sunita Ghosh, Clara Hwang   +8 more
wiley   +1 more source

Therapeutic Potential of Metal-Based and PARP Inhibitor Chemotherapy for <i>BRCA1</i>-Associated Triple-Negative Breast Cancer. [PDF]

Int J Mol Sci
Ratanaphan A.
europepmc   +1 more source

Albumin activates the AKT signalling pathway and protects B-chronics lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis [PDF]

, 2002
Anderson, RJ, Bruckdorfer, KR, Ganeshaguru, K, Hoffbrand, AV, Jackson, TR, Jones, DT, Low, SY, Mehta, AB, Palmqvist, L, Prentice, HG, Wickremasinghe, RG   +10 more
core  

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Real-world outcomes following PARP inhibitor maintenance in ovarian cancer by <i>BRCA</i> status: a retrospective cohort study. [PDF]

ESMO Real World Data Digit Oncol
Zucker K, Pickwell-Smith B, Samani A, Sujenthiran A, Pittell H, Mpofu P, Hall G.   +6 more
europepmc   +1 more source