Results 141 to 150 of about 6,402,525 (303)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Part-time work as a transitional phase? The role of preferences and institutions in Germany, Great Britain and The Netherlands.

This paper uses 11 years of data from household panel data sets for the Netherlands, Germany and Great-Britain to investigate part-time employment and the role of institutions and preferences on transitions from part-time into full-time employment or ...
Dekker, Ronald
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Underemployed women: an analysis of voluntary and involuntary part-time wage employment in South Africa

Using nationally representative household survey data from 1995 to 2006, this paper explores heterogeneity among female part-time wage (salaried) workers in post-apartheid South Africa, specifically distinguishing between individuals who choose to work ...
Colette Muller
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Alternative and Part-Time Employment Arrangements as a Response to Job Loss [PDF]

I examine the extent to which workers who lose jobs find work in alternative employment arrangements including temporary work and independent contracting and find part-time work, both voluntary and involuntary.
Henry S. Farber
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

WP 67 - The first part-time economy in the world. Does it work? [PDF]

_*This papers is republished from the first edition in 2000.*_ h2. Introduction In his Adam Smith lecture of the European Association of Labour Economists, Harvard economist Richard Freeman has defined the Netherlands as ‘the only part-time economy of ...
Jelle Visser
core  

Application of the Theory of Emergency Circumstances to Labor Relations in Light of the Coronavirus Pandemic

مجلة القانون، المجتمع والسلطة
This research paper seeks to explore the extent to which the Algerian state has implemented the theory of emergency circumstances in the context of labor relations during the coronavirus pandemic.
Asma Gouasmia
doaj