Results 61 to 70 of about 2,574,928 (152)

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

Innervation of the anal canal revisited through micro‐CT imaging

Journal of Anatomy, EarlyView.
This article demonstrates to utility of micro‐CT imaging for conduction micro‐CT experiments to explore the innervation of the pelvic area in human fetuses. It allows for the creation of intricate 3D models, which show that peripheral nerve crossings occur over the entire length of the rectum and hints towards development and sex related differences in
Daniël Docter, Sophie C. Visser, Marc A. Benninga, Jermo Hanemaaijer‐van der Veer, Marco C. DeRuiter, Joris J.T.H. Roelofs, Joep P. M. Derikx, Justin R. de Jong, Bernadette S. de Bakker, Ramon R. Gorter   +9 more
wiley   +1 more source

Phenotypic diversity in siblings with partial androgen insensitivity syndrome

, 1997
The androgen insensitivity syndrome is a heterogeneous disorder with a wide spec-trum of phenotypic abnormalities, rang-ing from complete female to ambiguous forms that more closely resemble males. The primary abnormality is a defective androgen receptor
Bevan, C. L., Gregory, John Welbourn, I A Hughes, B A J Evans, M N Patterson, Patterson, M. N., J W Gregory, C L Bevan, Hughes, I. A., Evans, Bronwen Alice James   +9 more
core   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Androgen insensitivity syndrome, a case report and literature review [PDF]

, 2017
A case of androgen insensitivity syndrome who presented with left labial mass and inguinal hernia was managed by surgery and counselling. The aim of this report is to present a rare case of androgen insensitivity syndrome, its cause, diagnosis and ...
V. M., Chaitanya, Malipatil, Pushpanjlai, Malipatil, Venkatreddy   +2 more
core   +1 more source

Prenatal exome sequencing of fetuses with central nervous system anomalies based on prenatal ultrasound and magnetic resonance imaging diagnosis: A retrospective cohort study with a systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1950-1964, October 2026.
Prenatal exome sequencing significantly improves diagnostic yield over chromosomal microarray analysis for fetal CNS abnormalities, with a diagnostic yield of 16% in our cohort and 27% in the meta‐analysis. Diagnostic yields vary across different phenotypes. Abstract Introduction Fetal central nervous system (CNS) abnormalities have diverse etiologies,
Jia Yao, Yan Wang, Gang Li, Zhitao Zhang, Yuan Lv, Lizhu Chen   +5 more
wiley   +1 more source

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley   +1 more source

The Physiological, Psychological and Genetic Expressions of XY Female Reporting at Tertiary Care Infertility Clinic of Kingdom of Saudi Arabia

Pakistan Journal of Medical Research, 2022
Background: Disorder in sex development (DSD) refers to a variety of diagnoses in which the development of chromosomal make-up, gonadal development, or anatomical development is abnormal.
Munazzah Rafique, Dania Al Jaroudi
doaj   +2 more sources

Simulating androgen receptor selection in designer yeast

Synthetic and Systems Biotechnology, 2022
Androgen receptor (AR) mutation is closely associated with prostate cancer (PCa) and is one of the mechanisms of resistance to PCa therapies such as AR antagonists. Although sequencing technologies like next-generation sequencing (NGS) contributes to the
Haoran Zhang, Lu Zhang, Yipeng Xu, Shaoyong Chen, Zhenyi Ma, Mingdong Yao, Fangyin Li, Bo Li, Yingjin Yuan   +8 more
doaj   +1 more source

A Two‐Stage Hybrid Feature Selection and Ensemble Learning Framework With Explainable AI for Accurate PCOS Prediction

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Polycystic ovary syndrome (PCOS) is the most prevalent endocrine ailment impacting women of reproductive age, distinguished by ongoing imbalances of hormones that lead to the growth of various ovarian cysts alongside other health issues.
Md. Rakibul Hasan Efty, Md. Naymur Rohman, Khandaker Mohammad Mohi Uddin, Md. Mahbubur Rahman, Md. Ashraf Uddin   +4 more
wiley   +1 more source