Results 71 to 80 of about 448,559 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Field Plate Integration for Mitigating Partial Discharge Activity in PCB-Embedded Power Electronic Modules

open access: yesEnergies
This paper proposes a concept based on field plate (FP) integration inside printed circuit board (PCB)-embedded power modules. The goal is to reduce the electric field at their surface and thus increase the partial discharge inception voltage (PDIV ...
Paul Bruyere, Eric Vagnon, Yvan Avenas
doaj   +1 more source

On some characterizations of antipodal partial cubes

open access: yesDiscussiones Mathematicae Graph Theory, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Partial Characterization of Oat and Rye Phytochrome [PDF]

open access: yesPlant Physiology, 1973
Purified oat and rye phytochrome were examined by analytical gel chromatography, polyacrylamide gel electrophoresis, N-terminal, and amino acid analysis. Purified oat phytochrome had a partition coefficient on Sephadex G-200 (sigma(200)) of 0.350 with an estimated molecular weight of 62,000; sodium dodecyl sulfate polyacrylamide electrophoresis gave an
H V, Rice, W R, Briggs
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Comparison of Continuous-Time Partial Markov Chain Construction by Heuristic Algorithms for Purpose of Approximate Transient Analysis

open access: yesMathematics
We investigate the construction of a partial absorbing continuous-time Markov chain (CTMC) using a heuristic algorithm aimed at approximate transient analysis.
Eimutis Valakevičius   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Strong approximation of Fourier series on generalized periodic Morrey spaces

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2018
In recent years, a lot of attention has been paid to study of Morrey type spaces. Many applications in partial differential equation of Morrey spaces and Lizorkin-Triebel spaces have been given in work G.Di Fazioand, M.
A.N. Adilkhanov   +2 more
doaj   +1 more source

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