Results 81 to 90 of about 111,104 (316)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
A Partial Functional Differential Equation
Journal of Mathematical Analysis and Applications, 2001 The author of this interesting paper investigates the partial functional differential equation \[ \partial u(x,t)\partial t =k \partial^2 u(x,t)\partial x^2+ru(x,t-T)[1-u(x,t)], \;\;t\geq 0, \;\;x\in [{}0,\pi ]{} \] under the boundary condition \(u(0,t)=u(\pi ,t)=0\) (\(t>0\)) and \(u(x,s)=\phi (x,s)\), \(-T\leq s\leq 0\), \(0\leq x\leq \pi \).
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Lattice Boltzmann model for high-order nonlinear partial differential equations [PDF]
, 2018 Zhenhua Chai +3 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Hyperholomorphic functions and higher order partial differential equations in the plane [PDF]
, 1990 R. Z. Yeh
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
A Complete Equational Axiomatisation of Partial Differentiation
Electronic Notes in Theoretical Computer Science, 2020 We formalise the well-known rules of partial differentiation in a version of equational logic with function variables and binding constructs. We prove the resulting theory is complete with respect to polynomial interpretations. The proof makes use of Severi's interpolation theorem that all multivariate Hermite problems are solvable.
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source