Results 91 to 100 of about 772,908 (331)

ON SINGULAR SOLUTIONS OF CLAIRAUT EQUATIONS IN THE THEORY OF ORDINARY DIFFERENTIAL AND PARTIAL DERIVATIVE EQUATIONS

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020
Background. There is no problem in finding a general solution to the ordinary differential Clairaut equation. The corresponding procedure is described in details in the theory of ordinary differential equations.
L. A. Zhidova
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Recent trends in highly accurate and structure-preserving numerical methods for partial differential equations [PDF]

, 2017
Quan Z. Sheng, Yifa Tang, Bruce A. Wade, Yushun Wang   +3 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Integral-Partial Differential Equations of Isaacs' Type Related to Stochastic Differential Games with Jumps [PDF]

, 2010
Rainer Buckdahn, Ying Hu, Juan Li
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

DeepDefend: A comprehensive framework for DDoS attack detection and prevention in cloud computing

Journal of King Saud University: Computer and Information Sciences
DeepDefend is an advanced framework for real-time detection and prevention of DDoS attacks in cloud environments. It employs deep learning techniques, notably CNN-LSTM-Transformer networks, to predict network traffic entropy and detect potential attacks.
Mohamed Ouhssini, Karim Afdel, Elhafed Agherrabi, Mohamed Akouhar, Abdallah Abarda   +4 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Advancements in detecting, preventing, and mitigating DDoS attacks in cloud environments: A comprehensive systematic review of state-of-the-art approaches

Egyptian Informatics Journal
This comprehensive study examines cutting-edge strategies for combating Distributed Denial of Service (DDoS) attacks in cloud environments, addressing a critical gap in recent literature. Through a systematic review of the latest advancements, we propose
Mohamed Ouhssini, Karim Afdel, Mohamed Akouhar, Elhafed Agherrabi, Abdallah Abarda   +4 more
doaj   +1 more source

A Method for Image Decontamination Based on Partial Differential Equation

MATEC Web of Conferences, 2015
This paper will introduce the method to apply partial differential equations for the decontamination processing of images. It will establish continuous partial differential mathematical models for image information and use specific solving methods to ...
Hou Junping
doaj   +1 more source