Results 51 to 60 of about 259,888 (302)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Characteristics of an x-ray preionized TEA CO laser [PDF]
, 1987 A cryogenically cooled sealed-off x-ray preionized self-sustained discharge CO laser was succesfully operated. It was found that 20 to 40% higher output energies could be obtained using x-ray instead of uv preionization.
Ernst, G.J., Zuidema, R.J.
core +9 more sources
Partial Discharge Analysis and Simulation Using the Consecutive Pulses Correlation Method
Energies, 2021 The behaviour of partial discharge as consequences of an alternating current (AC) is already well defined. AC partial discharges have completely different behaviour, background physics and parameters than partial discharges (PD) under direct current (DC)
Ondřej Kozák, Josef Pihera
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On-line transformer condition monitoring through diagnostics and anomaly detection [PDF]
, 2009 This paper describes the end-to-end components of an on-line system for diagnostics and anomaly detection. The system provides condition monitoring capabilities for two in- service transmission transformers in the UK.
Catterson, V.M. +3 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Analysis of Partial Discharge Measurements using Coupling Capacitor in Rotating Machine [PDF]
Iranian Journal of Electrical and Electronic EngineeringPartial discharge (PD) is a significant concern in the operation of rotating machines such as generators and motors, as it can lead to insulation degradation over time, reducing the reliability and lifespan of the machines.
Ahmad Syukri Abd Rahman +7 more
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