Results 91 to 100 of about 71,386 (306)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Surgery for Partial Epilepsy in Infancy

Pediatric Neurology Briefs, 1990
Focal resection of epileptic tissue was performed in five infants under one year of age with malignant partial seizures and deteriorating developmental status at Miami Children’s Hospital and the Comprehensive Epilepsy Center, Miami, FL.
J Gordon Millichap
doaj   +1 more source

Variants in BRWD3 associated with X-linked partial epilepsy without intellectual disability. [PDF]

CNS Neurosci Ther, 2023
Tian MQ, Liu XR, Lin SM, Wang J, Luo S, Gao LD, Chen XB, Liang XY, Liu ZG, He N, Yi YH, Liao WP, China Epilepsy Gene 1.0 Project.   +12 more
europepmc   +1 more source

Regional thalamic neuropathology in patients with hippocampal sclerosis and epilepsy: A postmortem study [PDF]

, 2013
Purpose Clinical, experimental, and neuroimaging data all indicate that the thalamus is involved in the network of changes associated with temporal lobe epilepsy (TLE), particularly in association with hippocampal sclerosis (HS), with potential roles in ...
Martinian, L, Sisodiya, SM, Sinjab, B, Thom, M   +3 more
core  

Continuous EEG source imaging enhances analysis of EEG-fMRI in focal epilepsy

, 2010
Introduction: EEG-correlated fMRI (EEG-fMRI) studies can reveal haemodynamic changes associated with Interictal Epileptic Discharges (IED). Methodological improvements are needed to increase sensitivity and specificity for localising the epileptogenic ...
Lemieux, L., Michel, C. M., Guye, M., Rodionov, R., Thornton, R., Vulliemoz, Serge, Carmichael, D. W., Lhatoo, S. D., Michel, Christoph, Duncan, J.S., Michel, C.M., Carmichael, D.W., Lhatoo, S.D., Guye, Maxime, Vulliemoz, S., Duncan, J. S.   +15 more
core   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Automated hippocampal segmentation in patients with epilepsy: Available free online

, 2013
Hippocampal sclerosis, a common cause of refractory focal epilepsy, requires hippocampal volumetry for accurate diagnosis and surgical planning. Manual segmentation is time-consuming and subject to interrater/intrarater variability.
Behr, C, Williams, EJ, Burdett, JL, Cardoso, MJ, Ourselin, S, Bartlett, PA, Espak, M, Duncan, JS, Winston, GP   +8 more
core  

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Recessive LAMA5 Variants Associated With Partial Epilepsy and Spasms in Infancy. [PDF]

Front Mol Neurosci, 2022
Luo S, Liu ZG, Wang J, Luo JX, Ye XG, Li X, Zhai QX, Liu XR, Wang J, Gao LD, Liu FL, Ye ZL, Li H, Gao ZF, Guo QH, Li BM, Yi YH, Liao WP.   +17 more
europepmc   +1 more source

The role of illness representations in the process of coping and psychosocial adjustment among adults with epilepsy [PDF]

, 1996
The self-regulation model (Leventhal, Nerenz and Steele, 1984) emphasises the role of cognitive representations of illness and coping efforts on patients responses to health threats.
Kemp, Steven
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