Results 91 to 100 of about 282,929 (321)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Towards a combined fractional mechanics and quantization

, 2012
A fractional Hamiltonian formalism is introduced for the recent combined fractional calculus of variations. The Hamilton-Jacobi partial differential equation is generalized to be applicable for systems containing combined Caputo fractional derivatives ...
Malinowska, Agnieszka B., Torres, Delfim F. M.   +1 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Homotopy Perturbation Method Combined with ZZ Transform to Solve Some Nonlinear Fractional Differential Equations

International Journal of Analysis and Applications, 2019
The idea proposed in this work is to extend the ZZ transform method to resolve the nonlinear fractional partial differential equations by combining them with the so-called homotopy perturbation method (HPM).
Lakhdar Riabi, Kacem Belghaba, Mountassir Hamdi Cherif, Djelloul Ziane   +3 more
doaj   +2 more sources

Vector Additive Decomposition for 2D Fractional Diffusion Equation

Nonlinear Analysis, 2008
Such physical processes as the diffusion in the environments with fractal geometry and the particles’ subdiffusion lead to the initial value problems for the nonlocal fractional order partial differential equations. These equations are the generalization 
N. Abrashina-Zhadaeva, N. Romanova
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Global Stability for Fractional Diffusion Equations in Biological Systems

Complexity, 2020
This paper proposes a new method of construction of Lyapunov functionals for the dynamical systems described by fractional differential equations and fractional partial differential equations. The proposed method is rigorously presented. Furthermore, the
Khalid Hattaf, Noura Yousfi
doaj   +1 more source

Domain decomposition methods for space fractional partial differential equations [PDF]

Journal of Computational Physics, 2017
In this paper, a two-level additive Schwarz preconditioner is proposed for solving the algebraic systems resulting from the finite element approximations of space fractional partial differential equations (SFPDEs). It is shown that the condition number of the preconditioned system is bounded by C(1+H/δ), where H is the maximum diameter of subdomains ...
Ying-Jun Jiang, Xuejun Xu
openaire   +3 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source