Results 141 to 150 of about 269,773 (341)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Resolvents of operators and partial functional differential equations with nonautonomous past
Journal of Mathematical Analysis and Applications, 2004 In this paper, for an abstract differential operator \(G\) corresponding to the integral equation \(u(t)=U(t,s)u(s)+\int_t^sU(t\xi)f(\xi)d\xi\) on a Banach space of \(X\)-valued functions on \({\mathbb{R}_-}\), where \(U(t,s)\) belongs to a backward evolution family, the author computes the resolvent of its restriction to a smaller domain to obtain a ...
openaire +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Finite Difference Approximation for Linear Stochastic Partial Differential Equations with Method of Lines [PDF]
A stochastic partial differential equation, or SPDE, describes the dynamics of a stochastic process defined on a space-time continuum. This paper provides a new method for solving SPDEs based on the method of lines (MOL).
McDonald, Stuart
core +1 more source
Backward difference replacements of the space derivative in first order hyperbolic equations [PDF]
, 1983 Two families of two-time level difference schemes are developed for the numerical solution of first order hyperbolic partial differential equations with one space variable.
Khaliq, AQM, Twizell, EH
core
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
On the covering dimension of the set of solutions of some nonlinear equations [PDF]
, 1986 We prove an abstract theorem whose sole hypothesis is that the degree of a certain map is nonzero and whose parametric equations are studied using cohomological mconclusions imply sharp, multidimensional continuation results.
Pejsachowicz, Jacobo +4 more
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
S-asymptotically omega-periodic solutions for abstract neutral differential equations
Electronic Journal of Differential Equations, 2015 In this article we study the existence of S-asymptotically omega-periodic solutions for abstract neutral functional differential equations recently, introduced in the literature.
Michelle Pierri, Donal O'Regan
doaj
Random and periodic homogenization for some nonlinear partial differential equations [PDF]
, 2009 textIn this dissertation we prove the homogenization for two very different classes of nonlinear partial differential equations and nonlinear elliptic integro-differential equations.
Schwab, Russell William, 1979-
core +1 more source