Results 41 to 50 of about 6,741,091 (278)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Asymptotic behavior of solutions of a partial functional differential equation
Electronic Journal of Differential Equations, 2000 The asymptotic behavior of solutions of an asymptotically autonomous partial functional differential equation is investigated. The aim of the present paper is to extend our earlier result for ordinary functional differential equations and difference ...
Gyula Farkas
doaj
On the existence of fuzzy solutions for partial hyperbolic functional differential equations [PDF]
International Journal of Computational Intelligence Systems, 2014 En este artículo, consideramos los problemas de frontera valorados para ecuaciones diferenciales funcionales hiperbólicas parciales difusas con condiciones de frontera locales e integrales. Se utiliza una nueva métrica ponderada para investigar la existencia y singularidad de soluciones difusas para estos problemas en un espacio métrico difuso completo.
Hoang Viet Long +3 more
openaire +2 more sources
Extrapolation techniques for first order hyperbolic partial differential equations [PDF]
, 1980 A uniform grid of step size h is superimposed on the space variable x in the first order hyperbolic partial differential equation ∂u/∂t + a ∂u/∂x = 0 (a > 0, x > 0, t > 0).
Twizell, E H
core +4 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Bounder solution on a strip to a system of nonlinear hyperbolic equations with mixed derivatives
Қарағанды университетінің хабаршысы. Математика сериясы, 2016 The system of nonlinear hyperbolic equations with mixed derivatives is considered on the strip. Time variable of the unknown function changes on the whole axis, and the spatial variable belongs to a finite interval.
D.S. Dzhumabaev, S.M. Temesheva
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Almost sure exponential stability of the Euler–Maruyama approximations for stochastic functional differential equations [PDF]
, 2011 By the continuous and discrete nonnegative semimartingale convergence theorems, this paper investigates conditions under which the Euler–Maruyama (EM) approximations of stochastic functional differential equations (SFDEs) can share the almost sure ...
Wu, Fuke +2 more
core +3 more sources