Results 61 to 70 of about 6,741,091 (278)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Periodic solutions for some partial neutral functional differential equations
Electronic Journal of Differential Equations, 2006 In this work, we study the existence of periodic solutions for partial neutral functional differential equation. We assume that the linear part is not necessarily densely defined and satisfies the Hille-Yosida condition.
Rachid Benkhalti +2 more
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FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
On a system of nonlinear partial functional differential equations
Novi Sad Journal of Mathematics, 2015 Summary: We consider a system of a semilinear hyperbolic functional differential equation (where the lower order terms contain functional dependence on the unknown functions) with initial and boundary conditions and a quasilinear elliptic functional differential equation (containing \(t\) as a parameter) with boundary conditions. Existence of solutions
openaire +2 more sources
Oscillation of higher-order neutral partial functional differential equations
Applied Mathematics Letters, 2003 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Wei Nian Li, Lokenath Debnath
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Inverse problem for a Fredholm third order partial integro-differential equation
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2014 The solvability of various problems for partial differential equations of the third order is researched in many papers. But, partial Fredholm integro-differential equations of the third order are studied comparatively less. Integro-differential equations
Tursun K Yuldashev
doaj +1 more source
Mild Solutions of Neutral Stochastic Partial Functional Differential Equations [PDF]
International Journal of Stochastic Analysis, 2011 This paper studies the existence and uniqueness of a mild solution for a neutral stochastic partial functional differential equation using a local Lipschitz condition. When the neutral term is zero and even in the deterministic special case, the result obtained here appears to be new. An example is included to illustrate the theory.
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Weak solutions of functional differential inequalities with first-order partial derivatives
Journal of Inequalities and Applications, 2011 The article deals with functional differential inequalities generated by the Cauchy problem for nonlinear first-order partial functional differential equations. The unknown function is the functional variable in equation and inequalities, and the partial
Kamont Zdzisław
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