Results 81 to 90 of about 6,741,091 (278)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Variation of constants formula for functional parabolic partial differential equations

Electronic Journal of Differential Equations, 2007
This paper presents a variation of constants formula for the system of functional parabolic partial differential equations $$displaylines{ frac{partial u(t,x)}{partial t} = DDelta u+Lu_t+f(t,x), quad t>0,; uin mathbb{R}^n cr frac{partial u(t,x ...
Hugo Leiva, Alexander Carrasco
doaj  

Genetic programming approaches for solving elliptic partial differential equations

, 2008
In this paper, we propose a technique based on genetic programming (GP) for meshfree solution of elliptic partial differential equations. We employ the least-squares collocation principle to define an appropriate objective function, which is optimized ...
Sobester, A., Keane, A.J., Nair, P.B., P.B. Nair, A.J. Keane, A. Sobester   +5 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

On functional differential equations associated to controlled structures with propagation

Electronic Journal of Qualitative Theory of Differential Equations, 2016
The method of integration along the characteristics has turned to be quite fruitful for qualitative analysis of physical and engineering systems described by large classes of partial differential equations of hyperbolic type in the plane (time and one ...
Vladimir Rasvan
doaj   +1 more source

A survey of partial differential equations in geometric design [PDF]

, 2008
YesComputer aided geometric design is an area where the improvement of surface generation techniques is an everlasting demand since faster and more accurate geometric models are required.
Willis, P., Ugail, Hassan, Palmer, Ian J., Gonzalez Castro, Gabriela   +3 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Resolvents of operators and partial functional differential equations with nonautonomous past

Journal of Mathematical Analysis and Applications, 2004
In this paper, for an abstract differential operator \(G\) corresponding to the integral equation \(u(t)=U(t,s)u(s)+\int_t^sU(t\xi)f(\xi)d\xi\) on a Banach space of \(X\)-valued functions on \({\mathbb{R}_-}\), where \(U(t,s)\) belongs to a backward evolution family, the author computes the resolvent of its restriction to a smaller domain to obtain a ...
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source