Results 81 to 90 of about 6,352,898 (223)

On functional differential equations associated to controlled structures with propagation

Electronic Journal of Qualitative Theory of Differential Equations, 2016
The method of integration along the characteristics has turned to be quite fruitful for qualitative analysis of physical and engineering systems described by large classes of partial differential equations of hyperbolic type in the plane (time and one ...
Vladimir Rasvan
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Resolvents of operators and partial functional differential equations with nonautonomous past

Journal of Mathematical Analysis and Applications, 2004
In this paper, for an abstract differential operator \(G\) corresponding to the integral equation \(u(t)=U(t,s)u(s)+\int_t^sU(t\xi)f(\xi)d\xi\) on a Banach space of \(X\)-valued functions on \({\mathbb{R}_-}\), where \(U(t,s)\) belongs to a backward evolution family, the author computes the resolvent of its restriction to a smaller domain to obtain a ...
openaire   +1 more source

Genetic programming approaches for solving elliptic partial differential equations

, 2008
In this paper, we propose a technique based on genetic programming (GP) for meshfree solution of elliptic partial differential equations. We employ the least-squares collocation principle to define an appropriate objective function, which is optimized ...
Sobester, A., Keane, A.J., Nair, P.B., P.B. Nair, A.J. Keane, A. Sobester   +5 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Almost Automorphic Mild Solutions to Neutral Parabolic Nonautonomous Evolution Equations with Nondense Domain

Discrete Dynamics in Nature and Society, 2013
Combining the exponential dichotomy of evolution family, composition theorems for almost automorphic functions with Banach fixed point theorem, we establish new existence and uniqueness theorems for almost automorphic mild solutions to neutral parabolic ...
Zhanrong Hu, Zhen Jin
doaj   +1 more source

Nonautonomous partial functional differential equations; existence and regularity

Nonautonomous Dynamical Systems, 2017
Abstract The aim of this work is to establish several results on the existence and regularity of solutions for some nondensely nonautonomous partial functional differential equations with finite delay in a Banach space. We assume that the linear part is not necessarily densely defined and generates an evolution family under the ...
Moussa El-Khalil Kpoumié, Khalil Ezzinbi, David Békollè   +2 more
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source