Results 91 to 100 of about 331,915 (277)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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Discrete Dynamics in Nature and Society, 2013 Combining the exponential dichotomy of evolution family, composition theorems for almost automorphic functions with Banach fixed point theorem, we establish new existence and uniqueness theorems for almost automorphic mild solutions to neutral parabolic ...
Zhanrong Hu, Zhen Jin
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Asymptotic pattern for a partial neutral functional differential equation
Journal of Differential Equations, 2015 The paper considers the following partial neutral functional differential equation \[ \begin{aligned} & \frac{\partial}{\partial t}\left[u(x,t)-b\,u(x,t-r)\right]=K\,\frac{\partial^2}{\partial x^2}\left[u(x,t)-b\,u(x,t-r)\right]\\ & +f(u(x,t)-b\,u(x,t-r),u(x,t),u(x,t-r)),\quad x\in\mathbb R, t>0, \end{aligned}\tag{NDDE} \] where \(K>0, r>0\) and \(00\)
Liu, Yubin, Weng, Peixuan
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Stability of a Class of Impulsive Neutral Stochastic Functional Partial Differential Equations
Discrete Dynamics in Nature and Society, 2020 In this paper, a class of impulsive neutral stochastic functional partial differential equations driven by Brownian motion and fractional Brownian motion is investigated.
Yue Liu, Dehao Ruan
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Dichotomy and periodic solutions to partial functional differential equations
Discrete & Continuous Dynamical Systems - B, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Nguyen Thieu Huy, Ngo Quy Dang
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
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Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
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A boundary value problem for nonlinear differential equation with arbitrary functions
Қарағанды университетінің хабаршысы. Математика сериясы, 2017 This article describes a semi-batch nonlinear boundary value problem for differential equations with partial derivatives. The equations containing arbitrary parameters were considered in Whitham G.B.
N. T. Orumbayeva, G. Sabitbekova
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