Results 101 to 110 of about 269,773 (341)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

The numerical solution of elliptic and parabolic partial differential equations with boundary singularities [PDF]

open access: yes, 1976
A general numerical method is described for the solution of linear elliptic and parabolic partial differential equations in the presence of boundary singularities.
Furzeland, RM, Crank, J
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Variation of constants formula for functional parabolic partial differential equations

open access: yesElectronic Journal of Differential Equations, 2007
This paper presents a variation of constants formula for the system of functional parabolic partial differential equations $$displaylines{ frac{partial u(t,x)}{partial t} = DDelta u+Lu_t+f(t,x), quad t>0,; uin mathbb{R}^n cr frac{partial u(t,x ...
Hugo Leiva, Alexander Carrasco
doaj  

On stochastic differential equations and a generalised Burgers equation [PDF]

open access: yes, 2012
In this paper, we discuss a link of Itˆo’s stochastic differential equa- tions to nonlinear partial differential equations of Burgers type. Un- der certain conditions, we derive a generalised Burgers equation from a stochastic differential equation.
Wu, JiangLun, Yang, Wei
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

On functional differential equations associated to controlled structures with propagation

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2016
The method of integration along the characteristics has turned to be quite fruitful for qualitative analysis of physical and engineering systems described by large classes of partial differential equations of hyperbolic type in the plane (time and one ...
Vladimir Rasvan
doaj   +1 more source

Some problems in irregular ordinary differential equations [PDF]

open access: yes
We study the non-autonomous ordinary differential equation x = f (t, x) in the situation when the vector field f is of limited regularity, typically belonging to a space LP (O,T; Lq (JRn)).
Sharples, Nicholas
core  

Chebyshev polynomial approximation for high-order partial differential equations with complicated conditions [PDF]

open access: yes, 2009
In this article, a new method is presented for the solution of high-order linear partial differential equations (PDEs) with variable coefficients under the most general conditions.
Akyüz-Daşcıoğlu, Ayşegül
core   +1 more source

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