Results 91 to 100 of about 26,170 (302)

Stability of a Class of Impulsive Neutral Stochastic Functional Partial Differential Equations

Discrete Dynamics in Nature and Society, 2020
In this paper, a class of impulsive neutral stochastic functional partial differential equations driven by Brownian motion and fractional Brownian motion is investigated.
Yue Liu, Dehao Ruan
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Implicit Partial Differential Equations: different approaching methods

, 2004
Implicit Partial Differential Equations: different approaching methods PhD Thesis of Giovanni Pisante Abstract In the last few decades the interest of scientists in nonlinear analysis has been constantly increasing and nonlinear partial ...
Pisante, Giovanni
core  

Functional Differential Equations

, 2018
The goal of this chapter is to apply the theories developed in the previous chapters to functional differential equations. In Section 7.1 retarded functional differential equations are rewritten as abstract Cauchy problems and the integrated semigroup ...
Pierre Magal, Ruan, Shigui, Magal, Pierre, Shigui Ruan   +3 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Almost Automorphic Mild Solutions to Neutral Parabolic Nonautonomous Evolution Equations with Nondense Domain

Discrete Dynamics in Nature and Society, 2013
Combining the exponential dichotomy of evolution family, composition theorems for almost automorphic functions with Banach fixed point theorem, we establish new existence and uniqueness theorems for almost automorphic mild solutions to neutral parabolic ...
Zhanrong Hu, Zhen Jin
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A boundary value problem for nonlinear differential equation with arbitrary functions

Қарағанды университетінің хабаршысы. Математика сериясы, 2017
This article describes a semi-batch nonlinear boundary value problem for differential equations with partial derivatives. The equations containing arbitrary parameters were considered in Whitham G.B.
N. T. Orumbayeva, G. Sabitbekova
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

On some properties of a system of nonlinear partial functional differential equations

Electronic Journal of Qualitative Theory of Differential Equations, 2016
We consider a system of a semilinear hyperbolic functional differential equation (where the lower order terms contain functional dependence on the unknown function) with initial and boundary conditions and a quasilinear elliptic functional differential ...
László Simon
doaj   +1 more source