Results 71 to 80 of about 26,170 (302)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Some problems in irregular ordinary differential equations [PDF]

open access: yes
We study the non-autonomous ordinary differential equation x = f (t, x) in the situation when the vector field f is of limited regularity, typically belonging to a space LP (O,T; Lq (JRn)).
Sharples, Nicholas
core  

Partial difference equations arising from the Cauchy-Riemann equations

open access: yesAnnales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2006
We consider some functional equations arising from the Cauchy-Riemann equations, and certain related functional equations. First we propose a new functional equation (E.1) below, over a $2$-divisible Abelian group, which is a discrete version of the ...
S. Haruki, S. Nakagiri
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

On the Cauchy problem for linear hyperbolic functional-differential equations [PDF]

open access: yes, 2001
summary:We study the question of the existence, uniqueness, and continuous dependence on parameters of the Carathéodory solutions to the Cauchy problem for linear partial functional-differential equations of hyperbolic type.
Šremr, Jiří   +2 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Analysis of complex nonlinear reaction-diffusion equations [PDF]

open access: yes, 2008
A mathematical analysis has been carried out for some nonlinear reaction- diffusion equations on open bounded convex domains Ω C R(^d)(d < 3) with Robin boundary conditions- Existence, uniqueness and continuous dependence on initial data of weak and ...
Al-Ofl, Abdalaziz Saleem
core  

Semi-analytical approach to initial problems for systems of nonlinear partial differential equations with constant delay [PDF]

open access: yes, 2017
summary:This paper deals with the differential transform method for solving of an initial value problem for a system of two nonlinear functional partial differential equations of parabolic type.
Šamajová, Helena
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

A class of alternate strip-based domain decomposition methods for elliptic partial differential Equations [PDF]

open access: yes, 2005
The domain decomposition strategies proposed in this thesis are efficient preconditioning techniques with good parallelism properties for the discrete systems which arise from the finite element approximation of symmetric elliptic boundary value problems
Mihai, Loredana Angela
core  

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