Results 71 to 80 of about 331,931 (281)

Inverse problem for a Fredholm third order partial integro-differential equation

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2014
The solvability of various problems for partial differential equations of the third order is researched in many papers. But, partial Fredholm integro-differential equations of the third order are studied comparatively less. Integro-differential equations
Tursun K Yuldashev
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Weak solutions of functional differential inequalities with first-order partial derivatives

open access: yesJournal of Inequalities and Applications, 2011
The article deals with functional differential inequalities generated by the Cauchy problem for nonlinear first-order partial functional differential equations. The unknown function is the functional variable in equation and inequalities, and the partial
Kamont Zdzisław
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On qualitative behavior of multiple solutions of quasilinear parabolic functional equations

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2020
We shall consider weak solutions of initial-boundary value problems for semilinear and nonlinear parabolic differential equations for $t\in (0,\infty )$ with certain nonlocal terms.
László Simon
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Partial difference equations arising from the Cauchy-Riemann equations

open access: yesAnnales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2006
We consider some functional equations arising from the Cauchy-Riemann equations, and certain related functional equations. First we propose a new functional equation (E.1) below, over a $2$-divisible Abelian group, which is a discrete version of the ...
S. Haruki, S. Nakagiri
doaj  

An Iterated Pseudospectral Method for Functional Partial Differential Equations [PDF]

open access: yes, 2005
Chebyshev pseudospectral spatial discretization preconditioned by the Kosloff and Tal-Ezer transformation [10] is applied to hyperbolic and parabolic functional equations. A Jacobi waveform relaxation method is then applied to the resulting semi-discrete
Mead, J., Zubik-Kowal, B.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

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