Results 151 to 160 of about 36,653 (266)

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Partial Hepatectomy [PDF]

, 2020
openaire   +1 more source

Temporal Biomolecular Processes Underlying Recovery Following 90% Partial Hepatectomy: A Proteomics Study in Rats

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Background Post‐hepatectomy liver failure (PHLF) remains a limitation in the surgical treatment of liver cancer. The 90% partial hepatectomy (PH) rat model reliably induces biochemical PHLF and high mortality, providing a unique platform for identifying molecular pathways necessary for successful liver regeneration.
Andrea Lund, Jakob Kirkegård, Jens Randel Nyengaard, Frank Viborg Mortensen, Mikkel Thy Thomsen   +4 more
wiley   +1 more source

Low‐intervention clinical trials in Spain: Do they progress?

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1438-1444, May 2026.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza, Mayro J. Cortés Pestana, Kristopher Amaro, Rosa M. Antonijoan, Caridad Pontes   +4 more
wiley   +1 more source

The Small Molecule H89 Facilitates Mesenchymal Stem Cell‐derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT The role of human umbilical cord mesenchymal stem cell‐derived extracellular vesicles (hUCMSC‐EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strategies targeting their secretion are inefficient and lack a clear mechanistic understanding.
Yu Fu, Yi Ma, Jiajun Zhang, Liwei Liang, Ting Li, Zeyi Guo, Zhongzhe Li, Lei Feng, Yi Wang, Guolin He, Shao Li, Yang Li, Xiaoping Xu, Hui Liao, Yi Gao   +14 more
wiley   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source

Partial hepatectomy

Journal of British Surgery, 1949
openaire   +2 more sources

The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background Liver‐related sarcopenia is a devastating systemic complication of chronic liver disease (CLD) driven by mechanisms extending beyond nutritional deficiency. However, the role of liver‐derived humoral factors remains unclear. We utilised a unique cohort of human skeletal muscle biopsies to test the hypothesis that serum conjugated ...
Motoh Iwasa, Akiko Eguchi, Motoyuki Kohjima, Teruo Miyazaki, Hiroshi Kitamura, Yuko Takami, Naoki Yamashita, Mina Tempaku, Kiyora Izuoka, Yoshinao Kobayashi, Yoshiyuki Takei, Akira Honda, Hayato Nakagawa, Tadashi Ikegami, Makoto Nakamuta, Jun Okabe, Aldo J. Montano‐Loza   +16 more
wiley   +1 more source

Proteomic Trajectories of Metabolic and Proteostatic Adaptation During Normothermic Liver Perfusion

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background Normothermic machine perfusion (NMP) enables metabolic restoration and viability testing of liver grafts, but current viability criteria incompletely predict post‐transplant outcomes. The molecular basis of graft resilience or biliary vulnerability remains unclear. This study aimed to characterise tissue‐level proteomic trajectories
Heithem Jeddou, Anne‐Aurélie Raymond, Jean‐William Dupuy, Cyril Dourthe, Hector Prudhomme, Eya Ben Nejma, Stylianos Tzedakis, Bruno Turlin, Pierre Allaume, Karim Boudjema, Michel Samson   +10 more
wiley   +1 more source

Xenoperfusion—The Transformative Role of Machine Perfusion in Xenotransplantation

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Florian Huwyler, Simon Stoerzer, Pierre‐Alain Clavien, Mark W. Tibbitt   +3 more
wiley   +1 more source