Results 51 to 60 of about 398,426 (282)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Tikrit Journal of Pure Science, 2023 Appear in Many Application Areas for Regression Analysis and Presence the case of More Than One Variable Dependent Affected by A variety of Explanatory Variable and at The Same Time The Number of Observation is Relatively Small Compared to The Number ...
Thafer Ramathan Muttar AL-Badrany +1 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Improving the Performance of Robust Partial Least Squares Regression Using an Iterative Approach
مجلة الغري للعلوم الاقتصادية والاداريةThe robust partial least squares regression method provides a solution to noise and outliers in the estimated models by maximizing the explanation ratios of the independent and dependent variables (determination coefficient). Three proposed methods were
Mahammad Mahmoud Bazid Bazid +1 more
doaj +1 more source
Optimization of wood flour acetylation by factorial design and partial least squares regression
Química Nova, 2012 Acetylation was performed to reduce the polarity of wood and increase its compatibility with polymer matrices for the production of composites. These reactions were performed first as a function of acetic acid and anhydride concentration in a mixture ...
Lisandra M. K. Nadal +3 more
doaj +1 more source
Atmosphere, 2021 The past decade has witnessed a rapid decline in the Arctic sea ice and therefore has raised a rising demand for sea ice forecasts. In this study, based on an analysis of long-term Arctic summer sea ice concentration (SIC) and global sea surface ...
Xiaochen Ye, Zhiwei Wu
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Higher-Order Partial Least Squares (HOPLS) : a generalized multi-linear regression method [PDF]
, 2012 A new generalized multilinear regression model, termed the Higher-Order Partial Least Squares (HOPLS), is introduced with the aim to predict a tensor (multiway array) Y from a tensor X through projecting the data onto the latent space and performing ...
Caiafa, Cesar Federico +7 more
core +4 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Robust continuum regression. [PDF]
Several applications of continuum regression (CR) to non-contaminated data have shown that a significant improvement in predictive power can be obtained compared to the three standard techniques which it encompasses (ordinary least squares (OLS ...
Croux, Christophe +3 more
core +3 more sources