Results 71 to 80 of about 297,317 (304)

The Purchase Decision to ABC Sauce in Kebumen Regency

Jurnal Social Economic of Agriculture, 2023
This analysis on purchasing decisions for ABC sauce in Kebumen Regency has the aim of knowing the effect of brand image, characteristic products, and cost on purchasing decisions for ABC sauces. This study was conducted on consumers who consume ABC brand
Winda Istianti, Heru Irianto, Erlyna Wida Riptanti   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

STRUCTURAL EQUATION MODELING (SEM) MENGGUNAKAN ALTERNATIF PARTIAL LEAST SQUARE (PLS) [PDF]

, 2021
Structural Equation Modeling (SEM) is a combination of factor analysis with path analysis into a comprehensive statistical method. SEM method with variant-based alternatives or often called Partial Least Square (PLS) is one of the methods used when the ...
PUTRI AYUNING TYAS, NIM. 17106010004
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Analisis Implementasi Sistem Informasi Keuangan, Kompetensi Pegawai dan Evaluasi Manajemen Terhadap Efektifitas Pengelolaan Keuangan Pada Unit Program Belajar Jarak Jauh Universitas Terbuka Seluruh Indonesia

Jurnal Manajemen, 2019
Financial management is one of the factors that determine the achievement of organizational goals. In order for financial management (budget) to run in an orderly and accountable financial information system.
Irwandi Irwandi
doaj   +1 more source

Pemodelan otentikasi komposisi fitofarmaka tensigard menggunakan regresi partial least square [PDF]

, 2008
Pemodelan kalibrasi menggambarkan bubungan antara absorban pada panjang gelombang tertentu sebagai peubah penjelas (X) dengan konsentrasi larutan unsur atau senyawa yang dianalisis sebagai peubah respon (Y).
Fedri, Rikola
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Partial Least Square Approach to Second Order Factor in Behavioural Study of Accounting Information System

SHS Web of Conferences, 2017
Theories are developed to explain an observed phenomenon in an effort to understand why and how things happen. Theories thus, use latent variables to estimate conceptual parameters.
Ibrahim Mohd Tarmizi, Roni Saiyidi Mat
doaj   +1 more source