Results 31 to 40 of about 76,426 (269)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Variable Upper Mantle Geochemical Processes Constrained From Independent Component Analysis of the Fizh Massif, Northern Oman Ophiolite

Geochemistry, Geophysics, Geosystems
We statistically analyzed the whole‐rock compositions of peridotites in the Oman ophiolite using a multivariate statistical technique called independent component analysis (ICA) to better understand the processes within the ophiolitic mantle section that
Yuto Miki, Eiichi Takazawa, Kenta Ueki, Tatsu Kuwatani   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The 1.79 Ga Särkilahti leucogranite – a horizontal magma layer below granulite-grade migmatites in SE Finland [PDF]

Bulletin of the Geological Society of Finland, 2019
The heterogeneous, peraluminous Särkilahti garnet-cordierite leucogranite occupies ~ 75 km2 area in Svecofennian granulite-grade terrain of SE Finland. Country rocks are metasedimentary garnet-cordierite-biotite migmatites with some orthopyroxenegarnet ...
Hannu Mäkitie, Hugh O´Brien, Olavi Selonen, Matti Kurhila   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Subvolcanic petrology of the Pico dos Três Estados region (SE Brazil): Implications for Alkaline Magmatic Evolution [PDF]

Brazilian Journal of Geology
This paper presents a geological study of the subvolcanic bodies present in the Pico dos Três Estados (São Paulo (SP), Rio de Janeiro (RJ), and Minas Gerais (MG)) and its surroundings at the Passa Quatro Alkaline Complex.
Graciano Carlos de Freitas, Artur Corval, Júlio Cesar Lopes da Silva, Helena Saraiva Koenow Pinheiro, Sérgio de Castro Valente   +4 more
doaj   +1 more source

Pressure-temperature conditions and significance of Upper Devonian eclogite and amphibolite facies metamorphisms in southern French Massif central

BSGF - Earth Sciences Bulletin, 2020
The southwestern French Massif central in western Rouergue displays an inverted metamorphic sequence with eclogite and amphibolite facies units forming the top of the nappe stack.
Benmammar Anissa, Berger Julien, Triantafyllou Antoine, Duchene Stéphanie, Bendaoud Abderrahmane, Baele Jean-Marc, Bruguier Olivier, Diot Hervé   +7 more
doaj   +1 more source

The age and origin of the Vaasa migmatite complex revisited [PDF]

Bulletin of the Geological Society of Finland, 2014
The origin of the Vaasa migmatite complex was studied by using whole-rock Sm-Nd and zircon Lu-Hf and U-Pb data in conjunction with whole-rock major and trace element geochemistry.
E. Suikkanen, H. Huhma, M. Kurhila, Y. Lahaye   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Van Gölü’nün doğusundaki Otlakbaşı bazaltik volkanizmasının petrolojik ve jeokimyasal evrimi

Bulletin of the Mineral Research and Exploration, 2018
Van Gölü’nün doğusundaki çarpışma ile ilişkili Otlakbaşı volkanizması farklı açılma çatlaklarından püskürerek meydana gelmiştir. Bu çalışmada, Otlakbaşı bazaltik volkanizmasının yeni yaş verisi ve ana oksit, iz ve nadir toprak element jeokimyasal ...
Vural OYAN
doaj   +1 more source