Results 41 to 50 of about 76,426 (269)

Petrogenesis of mafic-intermediate magmatism of the Michoacán–Guanajuato volcanic field in Western Mexico. A geochemical review

Frontiers in Earth Science, 2022
The Michoacán–Guanajuato volcanic field (MGVF) in the western Trans-Mexican Volcanic Belt is one of the largest and most diverse monogenetic volcanic fields in the world holding more than 1200 volcanic vents.
Darío Torres-Sánchez, Giovanni Sosa-Ceballos, Xavier Bolós, José Luis Macías   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Neoproterozoic magmatic accretion and Pan-African reworking-differentiation of mafic crust derived from an enriched mantle: evidences from structural analysis, petrology and geochemistry of the Ketté gold district (Eastern Cameroon)

BSGF - Earth Sciences Bulletin
The gold-rich Ketté formations belong to the Adamawa-Yadé block of the Neoproterozoic Central Africa Orogenic Belt. They consist of a complex association of tonalite, granodiorite, and heterogeneous granite including rafts of metapyroxenite, amphibolite,
Ngassam Mbianya Ghislain, Vanderhaeghe Olivier, Ganno Sylvestre, Gregoire Michel, Benoit Mathieu, Azefack Mbounou Rodolph Loïque, Takodjou Wambo Jonas Didero, Ngnotue Timoleon   +7 more
doaj   +1 more source

Tectono-metamorphic evolution and timing of the melting processes in the Svecofennian Tonalite-Trondhjemite Migmatite Belt: An example from Luopioinen, Tampere area, southern Finland [PDF]

Bulletin of the Geological Society of Finland, 1999
The Svecofennian Orogen is in southern Finland characterized by two major migmatite belts. These are the so-called Granite Migmatite Belt, in which Kfs-rich leucosomes predominate, and the Tonalite-Trondhjemite Migmatite Belt, which is characterized by ...
H. Mouri, K. Korsman, H. Huhma
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Temperature Distribution of Particles in a Laser Beam

Iranian Journal of Materials Science and Engineering, 2018
This article studies the particle temperature distribution depending on the laser radiation power and the particle’s trajectory and velocity. The uneven heating of particles moving in the laser radiation field is identified.
V. Lykhoshva, A. Tymoshenko, L. Mosentsova, V. Savin, D. Schitz   +4 more
doaj  

Tracking the exhumation of a Pliocene (U)HP terrane: U‐Pb and trace‐element constraints from zircon, D'Entrecasteaux Islands, Papua New Guinea

Geochemistry, Geophysics, Geosystems, 2014
Domal structures within the D'Entrecasteaux Islands of eastern Papua New Guinea expose ultrahigh‐pressure (UHP) Pliocene (5.6–4.6 Ma) eclogites and evidence for partial melting.
Joel W. DesOrmeau, Stacia M. Gordon, Timothy A. Little, Samuel A. Bowring   +3 more
doaj   +1 more source

Evolution of the volcanic mechanism in the central part of the Urumieh-Dokhtar magmatic arc

Journal of Economic Geology, 2021
Introduction Cenozoic volcanic activities in the Urumieh-Dokhtar Magmatic Arc (UDMA) have occurred in three main pulses of Eocene, upper Oligocene-Pliocene, and Pio-Quaternary (Dilek et al., 2010, Sayari, 2015).
Mohammad Sayari , Mortaza Sharifi
doaj   +1 more source

Spontaneous small‐scale melt segregation in partial melts undergoing deformation [PDF]

Geophysical Research Letters, 1989
A partial melt undergoing large scale deformation is shown to be unstable with respect to small scale redistribution of melt, provided the shear viscosity of the matrix depends on melt fraction. In the physically realistic case where melt “softens” the matrix, melt migrates along the direction parallel to the axis of minimum compressive stress and ...
openaire   +2 more sources