Results 41 to 50 of about 2,125,195 (285)

Differentiation of Planetesimals and the Thermal Consequences of Melt Migration [PDF]

, 2011
We model the heating of a primordial planetesimal by decay of the short-lived radionuclides Al-26 and Fe-60 to determine (i) the timescale on which melting will occur; (ii) the minimum size of a body that will produce silicate melt and differentiate; (iii) the migration rate of molten material within the interior; and (iv) the thermal consequences of ...
arxiv   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Melt-preferred orientation, anisotropic permeability, and melt-band formation in a deforming, partially molten aggregate [PDF]

, 2015
Shear deformation of partially molten rock in laboratory experiments causes the emergence of melt-enriched sheets (bands in cross-section) that are aligned at about 15-20 degrees to the shear plane. Deformation and deviatoric stress also cause the coherent alignment of pores at the grain scale.
arxiv   +1 more source

An observational and thermodynamic investigation of carbonate partial melting

Earth and Planetary Science Letters, 2015
Abstract Melting experiments available in the literature show that carbonates and pelites melt at similar conditions in the crust. While partial melting of pelitic rocks is common and well-documented, reports of partial melting in carbonates are rare and ambiguous, mainly because of intensive recrystallization and the resulting lack of criteria for ...
David Floess, David Floess, Lukas P. Baumgartner, Pierre Vonlanthen   +3 more
openaire   +4 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

"Early partial melting" in annealed natural cordierites

European Journal of Mineralogy, 2002
Natural cordierite crystals with a range of Mg:Fe ratios have been annealed at a range of temperatures between 1200 and 1430°C (under controlled f o2 ), after previously being annealed at 900 °C to drive off any volatiles contained within their channels. Complex microstructures were observed in these samples by transmission electron microscopy.
Capitani, G, Doukhan, J, Malchereck, T, Carpenter, M.   +3 more
openaire   +2 more sources

Dacite formation on Vesta: Partial melting of the eucritic crust

, 2017
The Dominion Range 2010 howardite pairing group contains an evolved lithic clast of dacite composition. The dacite contains an assemblage of plagioclase, quartz, and augite, with minor pigeonite, troilite, ilmenite, FeNi metal, K‐feldspar, and phosphates.
T. Hahn, N. Lunning, H. McSween, R. Bodnar, L. Taylor   +4 more
semanticscholar   +1 more source

New constraints on the timing of partial melting and deformation along the Nyalam section (central Himalaya): implications for extrusion models

Special Publications, 2015
New structural, U–Th/Pb and Ar/Ar data along the Nyalam section constrain the timing of partial melting, crystallization and deformation in the Greater Himalayan Sequence. Prograde metamorphism was followed by the onset of partial melting at c. 30 Ma. In
P. Leloup, Xiaobing Liu, G. Mahéo, J. Paquette, N. Arnaud, Alexandre Aubray, Xiaohan Liu   +6 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source