Results 91 to 100 of about 874,501 (291)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Uniform shift estimates for transmission problems and optimal rates of convergence for the parametric Finite Element Method

open access: yes, 2012
Let $\Omega \subset \RR^d$, $d \geqslant 1$, be a bounded domain with piecewise smooth boundary $\partial \Omega $ and let $U$ be an open subset of a Banach space $Y$.
Li, Hengguang, Nistor, Victor, Qiao, Yu
core   +3 more sources

Matrix partial orders through generalized inverses: unified theory

open access: yesLinear Algebra and its Applications, 1991
Auf der Menge der \(m\times n\)-Matrizen über einem Körper sind verschiedene (teilweise) Ordnungen speziell mit Hilfe geeigneter Mengen verallgemeinerter Inversen definierbar. Verf. unterwirft derartige Definitionen einem einheitlichen Prinzip: Es sei \({\mathcal G}\) eine Abbildung, die jeder entsprechenden Matrix A eine Menge \({\mathcal G}(A ...
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Design and Control of Fractional-Order Systems Based on Fractal Operators

open access: yesFractal and Fractional
In recent years, we have abstracted physical fractal space from biological structures and movements within living organisms, revealing the profound intrinsic connections between fractional order time and fractional-dimensional space, and providing ...
Zhimo Jian, Chaoqian Luo, Yajun Yin
doaj   +1 more source

Novel Dynamic Partial Reconfiguration Implementation of K-Means Clustering on FPGAs: Comparative Results with GPPs and GPUs

open access: yesInternational Journal of Reconfigurable Computing, 2012
K-means clustering has been widely used in processing large datasets in many fields of studies. Advancement in many data collection techniques has been generating enormous amounts of data, leaving scientists with the challenging task of processing them ...
Hanaa M. Hussain   +4 more
doaj   +1 more source

An efficient construction of polar codes based on the general partial order

open access: yesEURASIP Journal on Wireless Communications and Networking, 2019
Traditionally, the construction of polar codes requires intense computations to sort all bit channels. In previous works, two types of partial orders (POs) of polar codes were proposed to decrease the computations in the construction process.
Wei Wang, Liping Li, Kai Niu
doaj   +1 more source

Liveness Analysis in Explicitly-Parallel Programs [PDF]

open access: yes, 2016
International audienceIn this paper, we revisit scalar and array element-wise liveness analysis for programs with parallel specifications. In earlier work on memory allocation/contraction (register allocation or intra- and inter-array reuse in the ...
Darte, Alain   +2 more
core  

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