Results 71 to 80 of about 67,999 (265)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Solutions of the system of dual matrix equation AXB=B=BXA in two partial orders
Kuwait Journal of ScienceIn this paper, we consider the solutions of the system of dual matrix equation AXB=B=BXA in P-star partial order and D-star partial order, respectively.
doaj +1 more source
Shadow Cones: A Generalized Framework for Partial Order Embeddings
, 2023 ICLR ...
Tao Yu +3 more
openaire +3 more sources
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Various Definitions of Multiple Differentiability of a Function f: ℝn→ ℝ
Mathematics, 2020 Since the 17-th century the concepts of differentiability and multiple differentiability have become fundamental to mathematical analysis. By now we have the generally accepted definition of what a multiply differentiable function f:Rn→R is (in this ...
Alexander Kuleshov
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Design and Control of Fractional-Order Systems Based on Fractal Operators
Fractal and FractionalIn recent years, we have abstracted physical fractal space from biological structures and movements within living organisms, revealing the profound intrinsic connections between fractional order time and fractional-dimensional space, and providing ...
Zhimo Jian, Chaoqian Luo, Yajun Yin
doaj +1 more source