Results 61 to 70 of about 983,168 (284)

Testing Top Monotonicity [PDF]

open access: yes, 2014
Top monotonicity is a relaxation of various well-known domain restrictions such as single-peaked and single-crossing for which negative impossibility results are circumvented and for which the median-voter theorem still holds.
Aziz, Haris
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Computably Enumerable Partial Orders [PDF]

open access: yesComputability, 2012
We study the degree spectra and reverse-mathematical applications of computably enumerable and co-computably enumerable partial orders. We formulate versions of the chain/antichain principle and ascending/descending sequence principle for such orders, and show that the former is strictly stronger than the latter.
Cholak, Peter A.   +3 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Using spatial and temporal modeling to visualize the effects of U.S. state issued stay at home orders on COVID-19

open access: yesScientific Reports, 2021
Coronavirus disease 2019 dominated and augmented many aspects of life beginning in early 2020. Related research and data generation developed alongside its spread.
Rachel Carroll, Christopher R. Prentice
doaj   +1 more source

Core partial order in rings with involution

open access: yes, 2017
Let $R$ be a unital ring with involution. We give several characterizations and properties of core partial order in $R$. In particular, we investigate the reverse order law $(ab)^{\tiny\textcircled{\tiny\#}} = b^{\tiny\textcircled{\tiny\#}} a^{\tiny ...
Chen, Jianlong   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Solving Higher Orders Linear Complex Partial Differential Equations via Two Dimensional Differential Transform Method [PDF]

open access: yesمجلة جامعة الانبار للعلوم الصرفة
Complex partial differential equation (CPDEs( appeared around the year 1900. D. Pompeiu was a famous mathematician who left a large impact in this field through introducing the Pompeiu integral operator, which forms a basis in the subject CDEs.
Amal Alhassan   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy